ArticleEnvironmental science & technology letters2025
High-Throughput Small-Scale Platform for Synthesis, Characterization, and Modeling of Per- and Polyfluoroalkyl Substances Analogs.
Article in Environmental science & technology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Accelerated Chemistry in Microdroplets.Accounts of chemical research · 2026Article
- Early-stage drug discovery in a new-generation ultrahigh-throughput mass spectrometry platform.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Per- and polyfluoroalkyl substances (PFAS) are a global challenge due to their exceptional thermal and chemical durability which leads to environmental persistence, bioaccumulation, and toxicity. Tackling this challenge is a complex endeavor as the ever-expanding number of emerging PFAS hinders their monitoring while current countermeasures remain limited. Thus, there is a need for rapid strategies that can transform PFAS into safer, degradable analogs or expand libraries for untargeted monitoring. Here, we describe the implementation of a high-throughput (1 Hz) desorption electrospray ionization mass spectrometry (HT-DESI-MS) platform for the chemical transformation of perfluorocarboxylic acids (PFCAs) via a data-driven workflow that led to 915 new PFCA analogs (89% success rate) and revealed reactivity trends. Tandem mass spectrometry (MS/MS) enabled online structural confirmation and diagnostic fragment identification, supporting standard-free LC-MS/MS analysis. Further integration with ion mobility spectrometry (IMS) provided drift time measurements correlating with molecular size and shape, adding a new dimension that can improve feature annotation in untargeted PFAS analysis. Complementary quantum mechanical calculations of dipole moment and HOMO- LUMO gap predicted polarity and electronic reactivity, guiding analog selection. Collectively, this workflow combines rapid synthesis, structural annotation, and multidimensional profiling, with potential to discover safer PFAS and enhance environmental monitoring.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.