ArticleFrontiers in cellular and infection microbiology2026
Construction of a risk prediction model for premature rupture of membranes based on vaginal microecology and systemic inflammation: a prospective cohort study.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate whether vaginal microecological imbalance and group B Method: This study was a prospective single-center cohort study. A total of 162 singleton pregnant women at 28-37 weeks of gestation who were admitted to Jilin Provincial Maternal and Child Health Hospital from January 2023 to June 2024 were included. Among them, 81 cases were in the PROM group, and 81 cases were in the matched control group. Vaginal secretions were collected for microbiological testing (Nugent score, H Result: The GBS colonization rate in the PROM group was significantly higher (16.0% vs. 3.7%, aOR = 4.87, 95% CI 1.89-12.56). The incidence rates of abnormal vaginal microscopic evaluation (grades III-IV), H Conclusion: GBS colonization is associated with a higher incidence of PROM by inducing vaginal microecological imbalance and systemic inflammatory responses. The "microecology-inflammation" nomogram model we have developed shows potential for individualized prediction of the risk of PROM pending external validation, providing a basis for early intervention.
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