ArticleFrontiers in nutrition2026
A low-cost bedside nomogram integrating TSF and pain for predicting severe malnutrition in nasopharyngeal carcinoma: a prospective cohort study.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To examine the relationship between nutritional status and quality of life (QoL) in hospitalized patients with nasopharyngeal carcinoma (NPC), identify independent predictors of severe malnutrition, and establish a practical "low-cost" predictive nomogram to guide early clinical intervention. Methods: This study is a secondary analysis of a prospective cohort from the Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) project. We included 216 NPC patients prospectively enrolled at a participating center between January 2014 and December 2019. Clinical data, anthropometrics (including Triceps Skinfold Thickness, TSF), and patient-reported outcomes (NRS 2002 and pain scores) were collected upon admission. Patients were randomly split into a training cohort ( Results: Among the 216 patients (77.8% male; mean age 50.5 ± 10.6 years), 26.9% were at nutritional risk (NRS 2002 ≥ 3), and 23.2% suffered from severe malnutrition. Worsening nutritional status was significantly associated with lower functional domain scores and higher symptom burden in QoL ( Conclusion: Based on the prospective INSCOC dataset, we developed and validated a novel, low-cost bedside nomogram integrating NRS 2002, TSF, and Pain scores. By bypassing the need for blood tests, this tool enables immediate risk stratification for NPC patients, particularly in resource-limited settings, facilitating timely and personalized nutritional interventions.
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