Evidence map›Paper›PMID 41939206›Full record

ArticleTransplant international : official journal of the European Society for Organ Transplantation2026

Risk Assessment of Delayed Graft Function in Pediatric Kidney Transplantation - a CERTAIN Research Network Analysis.

Christian Patry, Miriam Boßung, Manuel Feißt, Kai Krupka, Britta Höcker, Lars Pape, Nele Kanzelmeyer, Lutz T Weber, Jun Oh, Atif Awan and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplant international : official journal of the European Society for Organ Transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Christian Patry *Department of Pediatrics I, Medical Faculty, Heidelberg University, University Children's Hospital Heidelberg, Heidelberg, Germany.
Miriam Boßung *Department of Pediatrics I, Medical Faculty, Heidelberg University, University Children's Hospital Heidelberg, Heidelberg, Germany.
Manuel FeißtInstitute of Medical Biometry, University of Heidelberg, Heidelberg, Germany.
Kai KrupkaDepartment of Pediatrics I, Medical Faculty, Heidelberg University, University Children's Hospital Heidelberg, Heidelberg, Germany.
Britta HöckerDepartment of Pediatrics I, Medical Faculty, Heidelberg University, University Children's Hospital Heidelberg, Heidelberg, Germany.
Lars PapeClinic for Paediatrics III, Essen University Hospital, Essen, Germany.
Nele KanzelmeyerDepartment of Pediatric Kidney, Liver, Metabolic and Neurological Diseases, Hannover Medical School, Hannover, Germany.
Lutz T WeberPediatric Nephrology, Children's and Adolescents' Hospital, University Hospital Cologne, Medical Faculty University of Cologne, Cologne, Germany.
Jun OhPediatric Nephrology, University Hospital Hamburg, Hamburg, Germany.
Atif AwanDepartment of National Paediatric Renal Transplantation, Children's Health Ireland at Temple Street, Dublin, Ireland.
Thomas SimonPediatric Nephrology, Toulouse University Hospital, Toulouse, France.
Licia PeruzziPediatric Nephrology Unit, Regina Margherita Children's Hospital, AOU Città della Salute e della Scienza di Torino, Torino, Italy.
Ali DuzovaDivision of Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Türkiye.
Jon Jin KimDepartment of Paediatric Nephrology, Nottingham University Hospital, Nottingham, United Kingdom.
Mohan ShenoyPaediatric Nephrology, Royal Manchester Children's Hospital, Manchester, United Kingdom.
Claus Peter SchmittDepartment of Pediatrics I, Medical Faculty, Heidelberg University, University Children's Hospital Heidelberg, Heidelberg, Germany.
Alexander FichtnerDepartment of Pediatrics I, Medical Faculty, Heidelberg University, University Children's Hospital Heidelberg, Heidelberg, Germany.
Burkhard TönshoffDepartment of Pediatrics I, Medical Faculty, Heidelberg University, University Children's Hospital Heidelberg, Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Delayed graft function (DGF) in pediatric kidney transplantation is a serious complication with negative impact on graft survival. Currently, there are no reliable methods available to assess the risk of DGF in children. We performed a retrospective analysis of data from the Cooperative European Paediatric Renal Transplant Initiative (CERTAIN) registry to develop a DGF risk assessment model for pediatric kidney transplantation, based on parameters available within the first 24 h post-transplant. The model was developed by forward selection and logistic regression. This study included n = 694 patients. The overall rate of DGF was 8.5%. The following key parameters were selected for the DGF risk assessment model: (i) occurrence of post-transplant surgical complications, (ii) immediate graft urine production, (iii) rate of change in recipient's serum creatinine, (iv) initial calcineurin inhibitor therapy. The significance of these parameters was confirmed by calculating adjusted odds ratios. In the training cohort and the internal validation cohort the ROC-AUCs were 0.9043 and 0.878. This multivariable model based on early post-transplant parameters can predict the occurrence of DGF in pediatric kidney transplant recipients with high accuracy and may facilitate future interventional trials of targeted pharmacological strategies against ischemia-reperfusion injury in this population.

Indexed as

Delayed Graft FunctionKidney TransplantationAdolescentChildChild, PreschoolCreatinineFemaleGraft SurvivalHumansInfantLogistic ModelsMalePostoperative ComplicationsRegistriesRetrospective StudiesRisk AssessmentCreatininedelayed graft functionischemia-reperfusion injurypediatric kidney transplantationpost-transplant complicationsrisk assessment model

Identifiers

PMID41939206
PMCPMC13045783

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.