A Comparison of Oliceridine versus Sufentanil for Patient-Controlled Analgesia After Total Knee Arthroplasty in Elderly Patients: A Double-Blinded Randomized Controlled Study.

Xi Liu, Suna Wang, Xiaoxiao Chen, Yuanyuan Tian, Junli Sun, Aizhong Wang, Qi Li, Hui Zhang

Abstract readComparative StudyRandomized Controlled Trial

In one paragraph

Trial report in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Oliceridine used for patient-controlled analgesia on postoperative quality of recovery in patients undergoing laparoscopic gynecological tumour resection: a randomized clinical trial.Annals of medicine · 2026
Trial

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xi Liu *Department of Anesthesiology, Shanghai Sixth People's Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

Suna Wang *Department of Clinical Research Center, Shanghai Sixth People's Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

Xiaoxiao Chen *Department of Anesthesiology, Shanghai Sixth People's Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

Yuanyuan TianDepartment of Anesthesiology, Shanghai Sixth People's Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

Junli SunDepartment of Anesthesiology, Shanghai Sixth People's Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

Aizhong WangDepartment of Anesthesiology, Shanghai Sixth People's Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

Qi LiDepartment of Anesthesiology, Shanghai Sixth People's Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

Hui ZhangDepartment of Anesthesiology, Shanghai Sixth People's Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Oliceridine is a G protein-biased μ-opioid receptor agonist, maintaining potent analgesic effects and simultaneously lessening disadvantageous reactions. This study is intended to compare Oliceridine and sufentanil patient-controlled analgesia (PCA) for postoperative analgesia in elderly patients suffering from knee arthroplasty. Patients and Methods: A total of 138 patients scheduled for knee arthroplasty were randomized to receive postoperative PCA with either Oliceridine (2 μg kg Results: Subjects in this research were 71.5 years on average, and 83% were female. Throughout 48 h postoperatively, the mean difference between Group Oliceridine and Group sufentanil was -7.13 (95% CI: -24.26 to 10.00); the upper bound of the 95% CI did not exceed the pre-specified non-inferiority margin of 10, thereby meeting the non-inferiority criterion. Aside from that, nausea (33.33% vs. 50.72%; P = 0.039) and vomiting (14.49% vs. 34.78%; P = 0.006) presented much lower incidence in Group Oliceridine within 48 h postoperative. Conclusion: Oliceridine may have non-inferior analgesic efficacy to sufentanil and is associated with a lowered incidence of nausea and vomiting within 48 h.

Indexed as

Analgesia, Patient-ControlledAnalgesics, OpioidArthroplasty, Replacement, KneePostoperative PainSufentanilAgedAged, 80 and overDouble-Blind MethodFemaleHumansMaleMiddle AgedSpiro CompoundsThiophenes((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amineAnalgesics, OpioidSpiro CompoundsSufentanilThiophenesoliceridinepain measurementpatient-controlled analgesiaPONVpostoperative nausea and vomitingTRV130

Identifiers

PMID41939437

DOI10.2147/DDDT.S587944

PMCPMC13050175

What Socratic holds

Textmetadata

LicenceCC BY-NC

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.