Trial reportFrontiers in medicine2026
Effects of remimazolam and sevoflurane on postoperative delirium and early cognitive impairment in elderly patients after laparoscopic-assisted gastrointestinal surgery: a randomized clinical trial.
Trial report in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Background: Postoperative delirium (POD) is a prevalent complication after surgery and anesthesia in elderly patients. Remimazolam and sevoflurane are two commonly used general anesthetics. This study aimed to evaluate the effects of remimazolam and sevoflurane on POD and early postoperative cognitive function in elderly patients. Methods: A total of 90 patients scheduled for laparoscopic-assisted gastrointestinal surgery under general anesthesia were recruited, and randomly assigned into three groups (n = 30 for each group): remimazolam (R), sevoflurane (S), and remimazolam combined with sevoflurane (RS) groups. After surgery, the incidence of POD and early postoperative cognitive impairment, postoperative pain score, recovery quality score, intraoperative drug dosage, and the incidence of intraoperative adverse reactions were assessed. Results: No significant differences were observed in the POD incidence ( Conclusion: Remimazolam was not associated with an increased incidence of POD or delayed recovery of early cognitive function in elderly patients. Moreover, it had a less pronounced impact on circulation compared to sevoflurane. Clinical trial registration: https://www.chictr.org.cn/showproj.html?proj=174731, identifier ChiCRT2200064984.
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