Evidence map›Paper›PMID 41939771›Full record

ArticleFrontiers in medicine2026

Proteomic profiling of spontaneous myopia in guinea pigs.

Hong Liu, Yongli Zhou, Xiaoning Li, Huixin Sun, Yuwen Hsiao, Longbo Wen, Qinglin Xu, Zhao Chen, Weizhong Lan, Zhikuan Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hong Liu *Changsha Aier Eye Hospital, Aier Eye Hospital Group, Aier Academy of Ophthalmology, Central South University, Changsha, Hunan, China.
Yongli Zhou *Changsha Aier Eye Hospital, Aier Eye Hospital Group, Aier Academy of Ophthalmology, Central South University, Changsha, Hunan, China.
Xiaoning LiChangsha Aier Eye Hospital, Aier Eye Hospital Group, Aier Academy of Ophthalmology, Central South University, Changsha, Hunan, China.
Huixin SunAier Institute of Optometry and Vision Science, Changsha, China.
Yuwen HsiaoChangsha Aier Eye Hospital, Aier Eye Hospital Group, Aier Academy of Ophthalmology, Central South University, Changsha, Hunan, China.
Longbo WenChangsha Aier Eye Hospital, Aier Eye Hospital Group, Aier Academy of Ophthalmology, Central South University, Changsha, Hunan, China.
Qinglin XuChangsha Aier Eye Hospital, Aier Eye Hospital Group, Aier Academy of Ophthalmology, Central South University, Changsha, Hunan, China.
Zhao ChenChangsha Aier Eye Hospital, Aier Eye Hospital Group, Aier Academy of Ophthalmology, Central South University, Changsha, Hunan, China.
Weizhong LanChangsha Aier Eye Hospital, Aier Eye Hospital Group, Aier Academy of Ophthalmology, Central South University, Changsha, Hunan, China.
Zhikuan YangChangsha Aier Eye Hospital, Aier Eye Hospital Group, Aier Academy of Ophthalmology, Central South University, Changsha, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: There is a subset of guinea pigs born with spontaneous myopia that exhibit fundus characteristics similar to those of high myopia. This study aimed to further identify the traits, including proteomic profiling of the retina and plasma, in this strain of guinea pigs. Methods: Spontaneously myopic guinea pigs ( Results: Compared to hyperopic eyes, spontaneously myopic eyes displayed a more negative RE ( Conclusion: Spontaneously myopic guinea pigs showed high similarity to human high myopia in ocular parameters, fundus, and molecular pathways, suggesting the potential as an alternative model for high myopia research.

Indexed as

complement cascadesexperimental myopiaferroptosisguinea pighigh myopiaproteomicsspontaneous myopia

Identifiers

PMID41939771
PMCPMC13043435

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.