Evidence map›Paper›PMID 41939774›Full record

ArticleFrontiers in medicine2026

Association between Epstein-Barr viral load and duration of hospitalization in pediatric infectious mononucleosis: a single-center retrospective study.

Zhi Yang, Zongtao Ma, Qingfeng Fang, Biquan Chen, Yuan Xu

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Zhi YangDepartment of Pediatric Infectious Disease, Anhui Provincial Children's Hospital, Hefei, China.
Zongtao MaDepartment of Pediatrics, Lixin Hospital of Chinese Medicine, Bozhou, China.
Qingfeng FangDepartment of Pediatric Infectious Disease, Anhui Provincial Children's Hospital, Hefei, China.
Biquan ChenDepartment of Pediatric Infectious Disease, Anhui Provincial Children's Hospital, Hefei, China.
Yuan XuDepartment of Pediatric Nephrology, Anhui Provincial Children's Hospital, Hefei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Epstein-Barr virus (EBV) infection exhibits considerable heterogeneity in clinical manifestations among children, ranging from self-limiting symptoms to severe complications. The role of viral load in disease progression remains incompletely understood. Objective: To investigate the relationship between EBV DNA load levels and clinical characteristics, treatment response, and prognosis in pediatric patients. Methods: A total of 192 children diagnosed with EBV infection and admitted to our hospital between January 2022 and October 2025 were included in the final analysis. Based on plasma EBV DNA levels at admission, patients were stratified into a high viral load group ( Results: Comparative analysis of baseline characteristics revealed that the high viral load group exhibited significantly elevated peak alanine aminotransferase (ALT) ( Conclusion: High EBV DNA load is independently associated with more severe hepatic injury, increased risk of complications, greater need for immunomodulatory therapy, and extended hospitalization. Viral load monitoring may facilitate early identification of children at high risk of unfavorable clinical outcomes.

Indexed as

childrenclinical outcomeCox regression analysisEpstein–Barr viruslength of stayviral load

Identifiers

PMID41939774
PMCPMC13046517

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.