ArticleJournal of Brown hospital medicine2026
Unprovoked Venous Thromboembolism in a Patient with a Small PNH Clone: A Therapeutic Dilemma.
Article in Journal of Brown hospital medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal hematopoietic stem cell disorder commonly presenting with hemolytic anemia and thrombosis. Treatment of acute thrombotic events usually involves a combination of complement inhibitor therapy and anticoagulation. We report the case of a 69-year-old female with history of PNH in spontaneous remission who presented nearly two decades later with unprovoked venous thromboembolism (VTE). Flow cytometry detected a small PNH without evidence of hemolysis, creating a dilemma regarding the need for complement inhibitor therapy. She was ultimately treated with anticoagulation alone. This case highlights the unknown aspects of the natural history of PNH and the challenges in managing venous thromboembolism in patients with persistent small PNH clones.
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