Cortical morphological changes in stroke-associated dysarthria patients.

Jin Zhou, Shilong Zhao, Wenjing Zhang, Tianyuan Wei, Hongxia Zhang, Weijin Liu, Chunlin Li, Xiaoxia Du

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In one paragraph

Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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8 authors.

Jin Zhou *Department of Neurorehabilitation, China Rehabilitation Research Center, Beijing, China.

Shilong Zhao *School of Biomedical Engineering, Capital Medical University, Beijing, China.

Wenjing Zhang *Beijing Stomatological Hospital, Capital Medical University, Beijing, China.

Tianyuan WeiDepartment of Rehabilitation, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Hongxia ZhangDepartment of Neurorehabilitation, China Rehabilitation Research Center, Beijing, China.

Weijin LiuDepartment of Neurorehabilitation, China Rehabilitation Research Center, Beijing, China.

Chunlin LiSchool of Biomedical Engineering, Capital Medical University, Beijing, China.

Xiaoxia DuDepartment of Neurorehabilitation, China Rehabilitation Research Center, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Post-stroke dysarthria (DYS) severely affects communication, yet cortical morphological alterations remain insufficiently characterized. This study applied surface-based morphometry (SBM) to examine cortical changes in DYS and their association with dysarthria severity assessed by the Frenchay Dysarthria Assessment (FDA). Methods: Forty-eight DYS patients and 72 matched controls underwent MRI. Cortical fractal dimension and gyrification were extracted via SBM. Group differences were tested using two-sample Results: DYS patients exhibited significantly increased fractal dimension in the left insula and elevated gyrification in bilateral insula, superior temporal and precentral gyri ( Conclusion: Cortical morphological alterations in insula and supramarginal gyrus may contribute to DYS pathophysiology. SBM provides quantitative markers linking cortical architecture to speech motor control, potentially guiding individualized rehabilitation strategies.

Indexed as

cortical structuredysarthriafractal dimensiongyrification indexstroke

Identifiers

PMID41940291

DOI10.3389/fneur.2026.1766268

PMCPMC13043395

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.