ArticleiScience2026
ASTROREPOMICS: A curated transcriptomic database for reproductive biology in space.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Spaceflight imposes substantial physiological stress on reproductive systems, yet relevant transcriptomic data remain fragmented across repositories. To address this need, we developed ASTROREPOMICS, a web-based platform that integrates 17 rigorously normalized and batch-corrected transcriptomic datasets spanning multiple species and reproductive tissues. The platform supports reproducible cross-study and cross-species analyses through standardized metadata and an intuitive user interface. We highlight its utility through two example analyses: (1) irradiated mouse sperm exhibited suppression of RNA splicing and protein-processing pathways alongside activation of interferon- and GPCR-associated programs; and (2) a multi-species intersected-DEG assessment between irradiated rat mammary tissue and microgravity-exposed zebrafish embryos uncovered conserved signatures involving RNA metabolism, cytokine signaling, and angiogenesis. By consolidating dispersed datasets and offering tailored analytical capabilities, ASTROREPOMICS provides a centralized resource for hypothesis generation and strengthens the research infrastructure needed to advance reproductive health studies in space, supporting long-term efforts to safeguard fertility during deep-space exploration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.