ArticleiScience2026
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Load-Dependent Effects of Sodium Glucose Co-Transporter Inhibitors on Work in Human Hypertrophic Cardiomyopathy Living Myocardial Slices.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To better understand pathomechanisms and drug responses in hypertrophic cardiomyopathy (HCM), long-term, reproducible human models for intact cardiac muscle are needed. To this end, we used the MyoDish tissue culture system for a 28-day culture of 73 living myocardial slices (LMSs) derived from myectomy samples of 14 HCM-patients. We defined the model's applicability in HCM by measuring contractility, myosin super relaxed to disordered relaxed state (SRX-DRX) ratios, mitochondrial function, and metabolic/proteomic profiles in LMS at days (D) 0, 14, and 28. Prominent changes in force, mitochondrial function, protein expression, and metabolism appeared in D14 and D28 slices compared to D0 (non-cultured) slices. Notably, the myosin SRX-DRX ratio and microtubule signatures were retained between D0 and D28, and contractility parameters were unchanged between D8 and D14. Our study indicates that drug interventions targeting these pathways are feasible, though culture conditions require further optimization to fully preserve an HCM-patient-specific profile.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.