ArticleiScience2026
Genetic evidence for causal roles of circulating proteins on breast cancer susceptibility.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circulating proteins represent promising candidates for understanding breast cancer (BC) etiology. This study employed a two-sample Mendelian randomization framework to investigate the potential causal relationships between genetically predicted levels of circulating proteins and BC risk. By integrating large-scale protein quantitative trait loci (pQTL) data from two major cohorts (DeCODE and UK Biobank) with BC genetic association data from three independent sources (FinnGen, BCAC), the analysis identified four proteins-intestinal alkaline phosphatase (ALPI), coiled-coil domain containing 134 (CCDC134), cadherin 1 (CDH1), and ST3 beta-galactoside alpha-2,3-sialyltransferase 2 (ST3GAL2)-with levels associated with a significantly reduced risk of BC. Colocalization analysis further supported a shared causal variant for ALPI. These proteins exhibited distinct associations with BC molecular subtypes. The findings highlight specific circulating proteins as potential mediators of BC risk. This work suggests avenues for exploring the biological mechanisms of BC and may inform future strategies for risk assessment.
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