Evidence map›Paper›PMID 41940338›Full record

ArticleiScience2026

Deletion of miR-130b/301b cluster promotes macrophage efferocytosis and resolution of adipose tissue inflammation.

Lei Yang, Tuerdiguli Abuduyimiti, Yibo Xi, Gianfilippo Coppola, Chen Liu, Shaoning Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lei YangDepartment of Pathology, School of Medicine, Yale University, New Haven, CT 06520, USA.
Tuerdiguli AbuduyimitiDepartment of Pathology, School of Medicine, Yale University, New Haven, CT 06520, USA.
Yibo XiDepartment of Pathology, School of Medicine, Yale University, New Haven, CT 06520, USA.
Gianfilippo CoppolaDepartment of Pathology, School of Medicine, Yale University, New Haven, CT 06520, USA.
Chen LiuDepartment of Pathology, School of Medicine, Yale University, New Haven, CT 06520, USA.
Shaoning JiangDepartment of Pathology, School of Medicine, Yale University, New Haven, CT 06520, USA.

Funding

Macrophage miR-130b/301b and beige adipogenesisR01DK138986 · YALE UNIVERSITY · 2025 to 2025
$451k
NIDDK NIH HHS R01 DK138986
6 · The paper itself

Abstract

Macrophage efferocytosis, the clearance of apoptotic cells, is essential for tissue homeostasis and preventing inflammation. Impaired efferocytosis contributes to chronic inflammatory conditions, including obesity. However, its key regulators remain unclear. MicroRNA-130b (miR-130b) is increased in adipose tissue macrophages of individuals with obesity. Here, we found that miR-130b was enriched in bone marrow of mice, and its expression in bone marrow-derived macrophages was suppressed by IL-4 and by apoptotic cell uptake. Deletion of the miR-130b and its cluster member miR-301b enhanced macrophage efferocytosis

Indexed as

cell biologyimmunologymolecular biology

Identifiers

PMID41940338
PMCPMC13049439

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.