Evidence map›Paper›PMID 41940341›Full record

ArticleiScience2026

Fibrin defines tissue stiffness and biomechanical signaling in regenerating zebrafish hearts as revealed by high-resolution stiffness mapping.

Juliane Münch, Tuli Pramanik, Isabell Tunn, Leona Simon, Claudia Jasmin Rödel, Shahrouz Amini, Peter Fratzl, Kerstin Blank, Ondine Cleaver, Salim Abdelilah-Seyfried

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Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Juliane MünchInstitute of Biochemistry and Biology, University of Potsdam, 14476 Potsdam, Germany.
Tuli PramanikDepartment of Molecular Biology and Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Isabell TunnFraunhofer Institute for Applied Polymer Research, 14476 Potsdam, Germany.
Leona SimonInstitute of Biochemistry and Biology, University of Potsdam, 14476 Potsdam, Germany.
Claudia Jasmin RödelInstitute of Biochemistry and Biology, University of Potsdam, 14476 Potsdam, Germany.
Shahrouz AminiDepartment of Biomaterials, Max Planck Institute of Colloids and Interfaces, 14476 Potsdam, Germany.
Peter FratzlDepartment of Biomaterials, Max Planck Institute of Colloids and Interfaces, 14476 Potsdam, Germany.
Kerstin BlankMechano(bio)chemistry, Max Planck Institute of Colloids and Interfaces, 14476 Potsdam, Germany.
Ondine CleaverDepartment of Molecular Biology and Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Salim Abdelilah-SeyfriedInstitute of Biochemistry and Biology, University of Potsdam, 14476 Potsdam, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myocardial infarction in humans causes an irreversible scar, which permanently impairs cardiac mechanical properties and physiological functions. The zebrafish heart resolves scar tissue and regenerates injured myocardium. To study mechanical properties during regeneration, we developed a method combining atomic force microscope-based nanoindentation with confocal microscopy and generated a high-resolution elasticity map of the zebrafish heart. This revealed distinct regions of stiffness within the injury site, including a stiff area that is cell-poor and fibrin-rich, contrasting with the softer injury center and surrounding myocardium. Whole-transcriptome analyses uncovered several components of the coagulation and fibrinolysis cascades in the regenerating heart. Pharmacological inhibition of the fibrinolysis regulator Serpine1 demonstrated that reduced fibrin-mediated stiffness impacts the biomechanical Hippo pathway in adjacent endocardial cells. Our approach characterizes the mechanical properties of different regions in the regenerating heart and shows that the biomechanical environment and mechanotransductive signaling are crucial components for understanding regenerative mechanisms.

Indexed as

Biological sciencesCardiovascular medicineMechanobiologyTissue engineering

Identifiers

PMID41940341
PMCPMC13049610

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.