ArticleiScience2026
Stimulation to secrete insulin induces pancreatic β-cell dysfunction through Tfe3 activation.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
During progression of diabetes, pancreatic β-cells gradually lose their ability to produce and secrete insulin. Dysfunction of β-cells is tightly associated with reduced expression of a set of glucose-stimulated insulin secretion (GSIS)-related genes, particularly the gene encoding Mafa, a transcription factor critical for β-cell functionality. However, the mechanisms underlying GSIS-related gene downregulation remain elusive. Here, we show that continuous supplementation of the drinking water of mice with glucose leads to nuclear accumulation of Tfe3, a transcription factor that responds to stress of the Golgi and lysosomes, in β-cells. This change was associated with Mafa downregulation and impairment of glucose tolerance. Acute stimulation of insulin secretion
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