ArticleGenetics and molecular biology2026
The dual role of sertraline: From antidepressant to antifungal drug with broad metabolic disruption.
Article in Genetics and molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Sertraline, a selective serotonin reuptake inhibitor, is a widely used antidepressant. In recent decades, research has revealed its potential for drug repurposing, demonstrating various biological activities beyond psychiatric applications, including antifungal, antibacterial, antitumor, anthelmintic, and leishmanicidal effects. This review explores the antifungal potential of sertraline and its possible mechanisms of action against fungal cells, highlighting similarities with its effects in higher eukaryotes. We examine the effects of sertraline on (1) gene expression pathways, (2) lipid and carbohydrate metabolism, (3) membrane function, (4) stress response, and (5) alternative splicing modulation. Finally, we discuss future perspectives on the use of sertraline as an antifungal agent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.