Evidence map›Paper›PMID 41942335›Full record

ArticleInternational neurourology journal2026

Cerebral Sympathetic Nervous System Activation Promotes Intrarenal Renin-Angiotensin System Activity and Salt-Induced Nocturnal Polyuria.

Go Tsujimura, Kentaro Takezawa, Teppei Wakita, Yuma Kujime, Hiroaki Kitakaze, Norichika Ueda, Shinichiro Fukuhara, Shuhei Kobuchi, Yoshihide Fujisawa, Akira Nishiyama and 4 more

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Article in International neurourology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Go TsujimuraDepartment of Urology, The University of Osaka Graduate School of Medicine, Suita, Japan.
Kentaro TakezawaDepartment of Urology, The University of Osaka Graduate School of Medicine, Suita, Japan.
Teppei WakitaDepartment of Urology, The University of Osaka Graduate School of Medicine, Suita, Japan.
Yuma KujimeDepartment of Urology, The University of Osaka Graduate School of Medicine, Suita, Japan.
Hiroaki KitakazeDepartment of Urology, The University of Osaka Graduate School of Medicine, Suita, Japan.
Norichika UedaDepartment of Urology, The University of Osaka Graduate School of Medicine, Suita, Japan.
Shinichiro FukuharaDepartment of Urology, The University of Osaka Graduate School of Medicine, Suita, Japan.
Shuhei KobuchiDivision of Pharmacology, School of Pharmacy, Department of Pharmacy, Hyogo Medical University, Kobe, Japan.
Yoshihide FujisawaDepartment of Pharmacology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
Akira NishiyamaDepartment of Pharmacology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
Hiromitsu NegoroDepartment of Urology, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
Yoshihisa KoyamaDepartment of Neuroscience and Cell Biology, The University of Osaka Graduate School of Medicine, Suita, Japan.
Shoichi ShimadaDepartment of Neuroscience and Cell Biology, The University of Osaka Graduate School of Medicine, Suita, Japan.
Norio NonomuraDepartment of Urology, The University of Osaka Graduate School of Medicine, Suita, Japan.

Funding

KAKENHI 2412506Salt Science Research Foundation 202530Salt Science Research Foundation 2434
6 · The paper itself

Abstract

purposeThis study was aimed at assessing the effects of cerebral sympathetic nervous system activity and renal denervation (RD) on the intrarenal renin-angiotensin system (RAS) and salt-induced nocturnal polyuria (NP).

methodsTo establish a mouse model, NP was induced by Nω-nitro-L-arginine methyl ester and a high-salt diet. Mice were subjected to dietary, pharmacological, and RD interventions, with blood pressure, urine output, renal norepinephrine, kidney protein expression, and c-Fos positive cells in the hypothalamic paraventricular nucleus (PVN) assessed using standardized physiological, biochemical, and histological methods.

resultsRenal angiotensinogen (AGT) and PVN c-Fos were significantly increased in NP model mice, indicating sympathetic activation. RD lowered renal AGT and the diurnal polyuria index versus sham (1.070±0.091 vs. 1.595±0.136 arbitrary units, P<0.01; 0.182±0.018 vs. 0.338±0.021, P<0.01).

conclusionCerebral sympathetic activation may promote intrarenal RAS activity and salt-induced NP; therefore, RD may be a potential therapeutic strategy to improve NP.

Indexed as

Nitric oxideNocturiaNocturnal polyuriaRenal denervationRenin-angiotensin systemSalt

Identifiers

PMID41942335
PMCPMC13053174

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.