Evidence map›Paper›PMID 41943124›Full record

ArticleJournal of clinical ultrasound : JCU2026

Analysis of the Safety of Single-Center Contrast-Enhanced Ultrasound in Pediatric Patients.

Lanxin Song, Xiuzhen Yang, Jingjing Qian, Jin Yu, Qingiming Liu, Zhisu Lv, Xiaoying Liu, Junjian Li, Xingpeng Fu, Jingjing Ye

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical ultrasound : JCU, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lanxin SongUltrasound Department, Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.ORCID https://orcid.org/0009-0009-6595-946X
Xiuzhen YangUltrasound Department, Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.ORCID https://orcid.org/0000-0001-8809-5099
Jingjing QianUltrasound Department, Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Jin YuUltrasound Department, Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Qingiming LiuUltrasound Department, Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Zhisu LvUltrasound Department, Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Xiaoying LiuUltrasound Department, Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Junjian LiUltrasound Department, Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Xingpeng FuUltrasound Department, Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Jingjing YeUltrasound Department, Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study retrospectively analyzed the safety of sulfur hexafluoride microbubble contrast-enhanced ultrasound (CEUS) in 447 pediatric patients (median age 8 years 4 months) at a single center. Using weight-based dosing (≤ 0.03 mL/kg of SonoVue), the overall adverse event incidence was 1.6% (7/447). Events included nausea/vomiting, severe cough, headache, rash, and transient hypertension, all mild and transient with no serious outcomes. All seven events were classified as mild, and no serious adverse events (e.g., anaphylactic shock, laryngeal edema) occurred in this study. No significant differences were found across gender or age groups. With standardized procedure and monitoring, CEUS demonstrated a highly favorable safety profile as a valuable radiation-free imaging tool in pediatrics.

Indexed as

Contrast MediaImage EnhancementPhospholipidsSulfur HexafluorideAdolescentChildChild, PreschoolFemaleHumansInfantMaleRetrospective StudiesUltrasonographycontrast agent BR1Contrast MediaPhospholipidsSulfur Hexafluorideadverse eventschildrencontrast‐enhanced ultrasoundsafety

Identifiers

PMID41943124
PMCPMC13540543

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.