ArticleJournal of translational medicine2026
TGFβ1-loaded extracellular matrix hydrogels promote skeletal muscle stem cell regeneration via m6A-mediated integrin-ERK signaling.
Article in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- RNA Chemical Modifications in Mammalian Skeletal Muscle Development, Homeostasis, and Disease: Regulatory Mechanisms and Chemical Biology Perspectives.Molecules (Basel, Switzerland) · 2026Review
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Authors and funding
5 authors.
Funding
Abstract
backgrounsSkeletal muscle stem cells (SkMSCs) are essential for muscle regeneration and represent a promising therapeutic target for muscle disorders. However, effective strategies to precisely regulate SkMSC fate by integrating biochemical and mechanical cues remain limited.
methodsA decellularized extracellular matrix (ECM) hydrogel replicating the native muscle microenvironment was developed. The hydrogel was loaded with TGFβ1 and applied to SkMSCs in vitro and in Sprague-Dawley rat models. Signaling activation, m6A methylation of integrin mRNA, ERK phosphorylation, and functional outcomes were assessed through molecular and physiological analyses.
resultsThe TGFβ1-loaded ECM hydrogel significantly enhanced SkMSC proliferation and differentiation by activating ERK signaling. Mechanistically, TGFβ1 promoted m6A methylation of integrin mRNA, leading to sustained ERK phosphorylation. In vivo, ECM hydrogels and TGFβ1 synergistically improved SkMSC function and muscle regeneration via m6A-modulated integrin signaling.
conclusionThis study reveals a novel m6A-mediated pathway that integrates biochemical (TGFβ1) and mechanical (ECM hydrogel) signals to direct SkMSC fate and provides a promising biomaterial-based strategy for treating muscle diseases through microenvironment-mimicking regenerative engineering.
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Registered trials
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