Evidence map›Paper›PMID 41943162›Full record

ArticleBiology of sex differences2026

Cortical thickness, surface area, and multisite pain: distinct patterns by sex in adolescence.

Esmeralda Hidalgo-Lopez, Christel Portengen, Tristin Smith, Hannah C Becker, Andrew Schrepf, Steven E Harte, Adriene M Beltz, Chelsea M Kaplan

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In one paragraph

Article in Biology of sex differences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Esmeralda Hidalgo-LopezChronic Pain and Fatigue Research Center, Department of Anesthesiology, University of Michigan Medical School, 24 Frank Lloyd Wright Dr., Lobby M, Suite 3100, Ann Arbor, MI, USA. esmehl@umich.edu.
Christel PortengenDepartment of Psychology, University of Michigan, 530 Church St, Ann Arbor, MI, USA.
Tristin SmithChronic Pain and Fatigue Research Center, Department of Anesthesiology, University of Michigan Medical School, 24 Frank Lloyd Wright Dr., Lobby M, Suite 3100, Ann Arbor, MI, USA.
Hannah C BeckerDepartment of Psychology, University of Michigan, 530 Church St, Ann Arbor, MI, USA.
Andrew SchrepfChronic Pain and Fatigue Research Center, Department of Anesthesiology, University of Michigan Medical School, 24 Frank Lloyd Wright Dr., Lobby M, Suite 3100, Ann Arbor, MI, USA.
Steven E HarteChronic Pain and Fatigue Research Center, Department of Anesthesiology, University of Michigan Medical School, 24 Frank Lloyd Wright Dr., Lobby M, Suite 3100, Ann Arbor, MI, USA.
Adriene M Beltz *Department of Psychology, University of Michigan, 530 Church St, Ann Arbor, MI, USA.
Chelsea M Kaplan *Chronic Pain and Fatigue Research Center, Department of Anesthesiology, University of Michigan Medical School, 24 Frank Lloyd Wright Dr., Lobby M, Suite 3100, Ann Arbor, MI, USA.

Funding

ABCD-USA Consortium:Research ProjectU01DA041028 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DUNCAN B. CLARK, BEATRIZ LUNA · 2015 to 2026
$13.9M
ABCD-USA Consortium: Research ProjectU01DA041022 · NIDA · SRI INTERNATIONAL · PI Fiona C Baker, Eva M Muller-Oehring · 2015 to 2026
$13.4M
NIDA NIH HHS U01 DA041022NIDA NIH HHS U01 DA041028NINR NIH HHS R01-NR020013
6 · The paper itself

Abstract

backgroundMultisite pain is common during adolescence and is influenced by sex-related neurobiological and developmental factors, but its developmental neural mechanisms are unclear.

methodsUtilizing data from the Adolescent Brain and Cognitive Development Study, we investigated the relation between cortical brain structure and multisite pain (assessed by youth self-reports of painful regions on a body map) in male (N = 3,299) and female (N = 2,844) adolescents aged 11-12 years. We focused on brain regions functionally linked to multisite pain (i.e., bilateral sensorimotor, cingulate, fronto-insular and inferior parietal cortex). We also explored the moderating role of pubertal status (assessed by the Pubertal Development Scale).

resultsFindings revealed distinct brain structure-pain associations in male and female youth. Male youth exhibited an inverse linear relation between cortical thickness of the left pre- and postcentral gyri and number of pain sites. Female youth exhibited a non-linear relation between surface area of the right supramarginal gyrus and number of pain sites. Pubertal status moderated the cingulate cortical thickness-pain association in males; those in early puberty had an inverse relation between anterior and mid cingulate cortex thickness and pain sites, whereas this relation was positive in those beyond mid-puberty.

conclusionThis study provides valuable insights into the sex-dependent neural organization linked to adolescent pain.

Indexed as

Brain Cortical ThicknessCerebral CortexPainSex CharacteristicsAdolescentChildFemaleHumansMagnetic Resonance ImagingMalePubertyAdolescenceBrain StructureMultisite PainPubertal DevelopmentSex Differences

Identifiers

PMID41943162
PMCPMC13181950

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.