Evidence map›Paper›PMID 41943164›Full record

ArticleBMC research notes2026

Effect of VSOR/VRAC blocker tamoxifen on contractile activity of primary neonatal cardiomyocytes and isolated perfused heart.

Galina V Maksimcheva, Navruz D Oljaev, Mukhriddin M Mansurov, Diyor D Fayziev, Nargiza A Tsiferova, Petr G Merzlyak, Ranokhon Sh Kurbannazarova, Iskandar F Abdullaev, Ravshan Z Sabirov

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Article in BMC research notes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Galina V Maksimcheva *Institute of Biophysics and Biochemistry, National University of Uzbekistan, Tashkent, 100174, Uzbekistan.
Navruz D Oljaev *Institute of Biophysics and Biochemistry, National University of Uzbekistan, Tashkent, 100174, Uzbekistan.
Mukhriddin M Mansurov *Institute of Biophysics and Biochemistry, National University of Uzbekistan, Tashkent, 100174, Uzbekistan.
Diyor D FayzievInstitute of Biophysics and Biochemistry, National University of Uzbekistan, Tashkent, 100174, Uzbekistan.
Nargiza A TsiferovaInstitute of Biophysics and Biochemistry, National University of Uzbekistan, Tashkent, 100174, Uzbekistan.
Petr G MerzlyakInstitute of Biophysics and Biochemistry, National University of Uzbekistan, Tashkent, 100174, Uzbekistan.
Ranokhon Sh KurbannazarovaInstitute of Biophysics and Biochemistry, National University of Uzbekistan, Tashkent, 100174, Uzbekistan.
Iskandar F AbdullaevInstitute of Biophysics and Biochemistry, National University of Uzbekistan, Tashkent, 100174, Uzbekistan.
Ravshan Z SabirovInstitute of Biophysics and Biochemistry, National University of Uzbekistan, Tashkent, 100174, Uzbekistan. zairovich@gmail.com.

Funding

Ministry of Higher Education, Science and Innovations of the Republic of Uzbekistan # FZ-202009216/F-OT-2021-157 and AL-9524115061
6 · The paper itself

Abstract

objectiveTamoxifen, a non-steroidal triphenylethylene antiestrogen, is a widely prescribed drug for treating and preventing estrogen receptor-positive breast cancer. The aim of this study was to evaluate the inotropic and chronotropic effects of tamoxifen on primary cultured neonatal cardiomyocytes and isolated adult Langendorff-perfused hearts.

resultsOsmotic swelling of primary cultured neonatal cardiomyocytes activated large anionic currents with the biophysical phenotype of the volume-sensitive outwardly rectifying (VSOR) chloride channel (also known as VRAC, volume-regulated anion channel). Tamoxifen at 10 µM suppressed VSOR/VRAC by ~ 84–85% in a voltage-independent manner. The same maneuver nearly stopped the spontaneous beating of the cardiomyocytes with no change in the contraction amplitude. In isolated Langendorff-perfused hearts, tamoxifen produced a significant negative chronotropic effect, as evidenced by a decrease in heart rate. No significant inotropic effect was observed, as there were no detectable changes in left ventricular systolic pressure, left ventricular developed pressure, and left ventricular end-diastolic pressure. At the single contraction level, administration of 10 µM tamoxifen resulted in broadening of the contraction amplitude histogram and a significant shift of the peak-to-peak interval histogram towards more prolonged values with signs of ectopic events.

Indexed as

HeartMyocardial ContractionMyocytes, CardiacTamoxifenAnimalsAnimals, NewbornCells, CulturedHeart RateIsolated Heart PreparationPerfusionRatsRats, WistarTamoxifenCell volume regulationChronotropic effectContractile activityInotropic effectLangendorff-perfused heartNeonatal cardiomyocytesTamoxifenVSOR/VRAC

Identifiers

PMID41943164
PMCPMC13181961

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.