ArticlePhysiological reports2026
STAT4-dependent regulation of neuroinflammation in atherosclerosis.
Natalie Stahr, Alina K Moriarty, Shelby D Ma, W Coles Keeter, Woong-Ki Kim, Larry D Sanford, Elena V Galkina
Abstract read
In one paragraphArticle in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
7 authors.
Natalie StahrDepartment of Biomedical and Translational Science, Eastern Virginia Medical School, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, Virginia, USA.
Alina K MoriartyDepartment of Biomedical and Translational Science, Eastern Virginia Medical School, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, Virginia, USA.
Shelby D MaDepartment of Biomedical and Translational Science, Eastern Virginia Medical School, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, Virginia, USA.
W Coles KeeterDepartment of Biomedical and Translational Science, Eastern Virginia Medical School, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, Virginia, USA.
Woong-Ki KimDivision of Microbiology, Department of Microbiology, Tulane National Primate Research Center, Covington, Louisiana, USA.
Larry D SanfordDepartment of Biomedical and Translational Science, Eastern Virginia Medical School, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, Virginia, USA.
Elena V GalkinaDepartment of Biomedical and Translational Science, Eastern Virginia Medical School, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, Virginia, USA.ORCID https://orcid.org/0000-0002-0001-685X Funding
Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4MMyeloid cell-specific role of STAT4 in atherosclerosis and metabolic dysfunctionR01HL142129 · NHLBI · EASTERN VIRGINIA MEDICAL SCHOOL · PI GALKINA, ELENA V, NADLER, JERRY L. · 2018 to 2021
$2.1MB cell anergy, modified LDL uptake, and atherosclerosisR01HL139000 · NHLBI · EASTERN VIRGINIA MEDICAL SCHOOL · PI GALKINA, ELENA V · 2018 to 2021
$1.9MAmerican Heart Association (AHA) 20PRE35180156HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL142129-04S1HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL139000HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL142129NIH HHS P51 OD011104
6 · The paper itselfAbstract
Atherosclerosis is linked to an increased risk of cognitive decline, with chronic inflammation being a common feature of both pathologies. IL-12 activates STAT4 to regulate myeloid cell functions, and blockade of this pathway alleviates cognitive impairment in Alzheimer's models. However, the mechanisms connecting vascular pathology to neuroinflammation remain unclear. Here, we examine whether STAT4 functions as a common mediator of neuroinflammation in atherosclerosis. We demonstrate that LysM
Indexed as
AtherosclerosisNeuroinflammatory DiseasesSTAT4 Transcription FactorAnimalsBrainEfferocytosisMaleMiceMice, Inbred C57BLMice, KnockoutMicrogliaReceptors, LDLReceptors, LDLStat4 protein, mouseSTAT4 Transcription Factoratherosclerosiscognitive functionsimmune responseneuroinflammationSTAT4
Identifiers
PMID41943474
PMCPMC13053938
What Socratic holds
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LicenceCC BY
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