Evidence map›Paper›PMID 41943648›Full record

ArticleClinical endoscopy2026

Impact of glucagon-like peptide-1 receptor agonists on colonoscopy outcomes: a systematic review and meta-analysis.

Ahmad Abdulraheem, Bara Abujaber, Lindsay Ayers, Usman Afzal, Dania Qarkash, Nadera Altork, Qusai Al-Zureikat, Kiandokht Bashiri, Ghaith Almhanni, Peppas Spyros and 1 more

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Article in Clinical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ahmad AbdulraheemDepartment of Internal Medicine, MedStar Washington Hospital Center, Washington, DC, USA.
Bara AbujaberDepartment of Internal Medicine, MedStar Washington Hospital Center, Washington, DC, USA.
Lindsay AyersDepartment of Medicine, School of Medicine, Georgetown University, Washington, DC, USA.
Usman AfzalDepartment of Internal Medicine, MedStar Washington Hospital Center, Washington, DC, USA.
Dania QarkashDepartment of Internal Medicine, School of Medicine, University of Jordan, Amman, Jordan.
Nadera AltorkDepartment of Internal Medicine, MedStar Washington Hospital Center, Washington, DC, USA.
Qusai Al-ZureikatDepartment of Internal Medicine, MedStar Washington Hospital Center, Washington, DC, USA.
Kiandokht BashiriDepartment of Internal Medicine, MedStar Washington Hospital Center, Washington, DC, USA.
Ghaith AlmhanniDepartment of Internal Medicine, MedStar Washington Hospital Center, Washington, DC, USA.
Peppas SpyrosDepartment of Internal Medicine, MedStar Washington Hospital Center, Washington, DC, USA.
Won Kyoo ChoDepartment of Medicine, School of Medicine, Georgetown University, Washington, DC, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGlucagon-like peptide-1 receptor agonists (GLP-1 RAs) are widely prescribed for diabetes and obesity. Recent studies suggest they may negatively affect bowel preparation quality before colonoscopy (CLN), leading to inadequate bowel preparation (IBP) and repeat procedures. We conducted a systematic review and meta-analysis to assess this association.

methodsPubMed, Embase and Cochrane databases, along with abstracts from Digestive Disease Week 2024 and the American College of Gastroenterology Meeting 2024, were searched. Outcomes included IBP, repeat CLNs, and the mean difference in Boston Bowel Preparation Scale (BBPS) scores between GLP-1 RA users and non-users. Adjusted odds ratios (OR), for age, sex, body mass index, and diabetes, were pooled.

resultsTwelve studies including 123,858 patients (57,699 GLP-1 RA users) were analyzed. GLP-1 RA use was associated with higher IBP risk (OR, 1.55; 95% CI, 1.11-2.16); adjusted analyses confirmed this (OR, 2.35; 95% CI, 2.02-2.74). BBPS scores were lower among GLP-1 RA users (mean difference, -0.68; 95% CI, -0.77 to -0.58). No association with repeat CLNs was observed (OR, 1.5; 95% CI, 0.88-2.56).

conclusionsGLP-1 RA use is linked to inadequate bowel preparation but not repeat CLNs. Further prospective studies are warranted to further evaluate this finding.

Indexed as

Boston bowel preparation scaleBowel preparationColonoscopyGlucagon-like peptide 1 receptor agonists

Identifiers

PMID41943648
PMCPMC13058711

What Socratic holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.