Trial reportPhysiotherapy research international : the journal for researchers and clinicians in physical therapy2026
Acute Effect of Transcutaneous Auricular Vagus Nerve Stimulation in Two Different Locations on Blood Pressure and Cardiac Autonomic Modulation in Healthy and Hypertensive Individuals: Pilot Study of a Randomized Crossover Clinical Trial.
Trial report in Physiotherapy research international : the journal for researchers and clinicians in physical therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
backgroundand PurposeTranscutaneous auricular vagus nerve stimulation (taVNS) has emerged as a promising noninvasive strategy to modulate autonomic function and reduce blood pressure (BP). However, whether the stimulation site influences acute cardiovascular responses remains unclear.
objectiveTo compare the acute effects of taVNS applied to the tragus and cymba conchae on BP and cardiac autonomic modulation in hypertensive and healthy individuals.
methodsThis pilot randomized crossover clinical trial included 14 hypertensive and 14 healthy participants who underwent two taVNS sessions (tragus and cymba conchae) in randomized order, one week apart. Sessions lasted 30 min and delivered a sinusoidal current (30 Hz, 500 ms pulse width), with intensity adjusted to the individual sensory threshold. Systolic BP (SBP), diastolic BP (DBP), and heart rate variability (HRV) parameters were assessed at baseline, during stimulation, and post-stimulation. Generalized estimating equations were used for analysis.
resultsA significant group × time × stimulation site interaction was observed for SBP (χ DISCUSSION: Acute taVNS induces site- and group-dependent cardiovascular responses, with limited clinical impact after a single session. These findings suggest that short-term stimulation may be insufficient to overcome impaired autonomic regulation in hypertension and highlight the need for repeated or longer stimulation protocols in future clinical trials.
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