ArticleMicrobiology spectrum2026
Analysis of putative heme ligands in the System I bacterial cytochrome
Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Heme is a key co-factor for biologically important proteins that are required for critical cellular functions such as oxygen transport and energy production. Yet heme is highly cytotoxic and is proposed to require specific transport pathways to move within cells. Despite its importance, mechanisms for heme transport remain largely uncharacterized due to heme's cytotoxicity and the transient nature of transport. In recent years, bacterial cytochrome IMPORTANCE: Heme is a critical co-factor for proteins with essential biological functions including gas sensing and electron transport. However, free or unbound heme is highly toxic to cells. To mitigate toxicity, there must be specific pathways to move heme in cells. While heme transport proteins have been identified genetically, their mechanism of transport remains elusive. The bacterial cytochrome
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