Evidence map›Paper›PMID 41944693›Full record

ReviewComprehensive Physiology2026

Look Who Is Talking: Extracellular Vesicles as Mediators of Intercellular and Interorgan Communication.

Michela Saviana, Giulia Romano, Daniel Del Valle-Morales, Mario Acunzo, Patrick Nana-Sinkam

Abstract readReview
In one paragraph

Review in Comprehensive Physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michela SavianaDivision of Pulmonary Diseases and Critical Care Medicine, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.
Giulia RomanoDivision of Pulmonary Diseases and Critical Care Medicine, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.
Daniel Del Valle-MoralesDivision of Pulmonary Diseases and Critical Care Medicine, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.ORCID 0000-0003-3881-8601
Mario AcunzoDivision of Pulmonary Diseases and Critical Care Medicine, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.
Patrick Nana-SinkamDivision of Pulmonary Diseases and Critical Care Medicine, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.

Funding

American Lung Association LCDA-922902National Center for Advancement of Translational Science 5K12TR004364-02NCI NIH HHS 5UG1CA287017-02NIH HHS NIH 1R21CA277525-01
6 · The paper itself

Abstract

Extracellular vesicles (EVs) are produced by every organ, serving as vehicles for communication. By circulating throughout the body and targeting both neighboring and distant cells and organs, they can drive downstream signaling. EVs play a role as effectors of cell-to-cell communication in the tissue microenvironment and have demonstrated their importance in driving downstream biological processes, maintenance of homeostasis and response to stimuli. New methodologies supporting the study of EV-mediated long-distance communication have revealed a whole new unexplored function in maintaining homeostasis of the organism and serving as indicators of pathological conditions. In this review, we provide the most recent update on the role of EVs as mediators of intercellular and interorgan communication.

Indexed as

cell‐to‐cell communicationextracellular vesiclesinterorgan communication

Identifiers

PMID41944693
PMCPMC13055575

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.