ArticleAging2026
Toward actionable interventions in human aging (12th ARDD meeting, 2025).
Abstract read
In one paragraph
Article in Aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
105 authors.
Aleksandr DekanDepartment of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Sierra LoreDepartment of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Ye Eun YoonDepartment of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Aisyah SjöholmInsilico Medicine AI, Abu Dhabi, United Arab Emirates.
Alexander TyshkovskiyDivision of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
Alexey TerskikhHarry Perkins Institute of Medical Research and University of Western Australia, Perth, WA, Australia.
Ana Maria CuervoEinstein Institute for Aging Research, Albert Einstein College of Medicine, New York, NY 10461, USA.
Anastasia GeorgievskayaHautAI OU, Tallinn, Estonia.
Andrea HeinzDepartment of Pharmacy, LEO Foundation Center for Cutaneous Drug Delivery, University of Copenhagen, Copenhagen, Denmark.
Andrei SeluanovDepartment of Biology and Medicine, University of Rochester, Rochester, NY 14609, USA.
Andrew AdamsEli Lilly and Company, Indianapolis, IN 46225, USA.
Andy P TsaiDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA.
Anna MurrayDepartment of Clinical and Biomedical Science, Faculty of Health and Life Science, University of Exeter, Exeter, UK.
Anne BrunetDepartment of Genetics, Stanford University, Stanford, CA 94305, USA.
Anne Marije van HartenApollo Health Ventures, Luxembourg City, Luxembourg.
Avi SpierNovartis, Cambridge, MA 02139, USA.
Ben ShenharDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Bente Klarlund PedersenCentre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Berthil ClasenEli Lilly and Company, Indianapolis, IN 46225, USA.
Björn SchumacherInstitute for Genome Stability in Ageing and Disease, Cologne Cluster of Excellence on Aging and Aging-Associated Diseases (CECAD), University and University Hospital of Cologne, Cologne, Germany.
Brian K KennedyCentre for Healthy Longevity, National University Health System, Singapore, Singapore.
Charlotte SuettaDepartment of Geriatric and Palliative Medicine, Copenhagen University Hospital, Bispebjerg and Frederiksberg, University of Copenhagen, Copenhagen, Denmark.
Christiane VolbrachtNeuroscience, H. Lundbeck A/S, Valby, Denmark.
Christoph KuppeDivision of Nephrology and Clinical Immunology, RWTH Aachen University, Medical Faculty, Aachen, Germany.
Clive CooksonFinancial Times, London, UK.
Collin Y EwaldNovartis Biomedical Research, Diseases of Aging and Regenerative Medicine, Basel, Switzerland.
Cristiana BanilaMitra Bio, Translation and Innovation Hub, London, UK.
Daisy CaiB Capital, Manhattan Beach, CA 90266, USA.
Dario Riccardo ValenzanoLeibniz Institute on Aging, Fritz Lipmann Institute (FLI), Jena, Germany.
Dudley W LammingDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI 53706, USA.
Edward RudnicMaxwell Biosciences, Austin, TX 78738, USA.
Elias Bou SamraL’Oréal Research and Innovation, Aulnay-sous-Bois, France.
Emma TeelingSchool of Biology and Environmental Science, University College Dublin, Dublin, Ireland.
Eric VerdinBuck Institute for Research on Aging, Novato, CA 94945, USA.
Evandro Fei FangDepartment of Clinical Molecular Biology, University of Oslo, Oslo, Norway.
Fabrizio d'Adda di FagagnaIFOM, Milan, Italy and IGM-CNR, Pavia, Italy.
Fedor GalkinInsilico Medicine AI, Abu Dhabi, United Arab Emirates.
Garri ZmudzeLongeVC, Washington, DC 20036, USA.
Heinrich JasperGenentech Inc., South San Francisco, CA 94080, USA.
In Hwa JangMasonic Institute on the Biology of Aging and Metabolism (MIBAM), University of Minnesota, Minneapolis, MN 55455, USA.
Jing-Dong Jackie HanCenter for Quantitative Biology, Peking University, Beijing, China.
Jamie JusticeXPRIZE Healthspan, Los Angeles, CA 90401, USA.
Jan H J HoeijmakersInstitute for Genome Stability in Ageing and Disease, Cologne Cluster of Excellence on Aging and Aging-Associated Diseases (CECAD), University and University Hospital of Cologne, Cologne, Germany.
Javier María Peralta RamosDepartment of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel.
Jean-Marc LemaitreInstitute for Regenerative Medicine and Biotherapy (IRMB), University of Montpellier, INSERM, Montpellier, France.
Jeroen AerssensRejuvenate Biomed, Diepenbeek, Belgium.
Joe Betts-LaCroixRetro Biosciences, Redwood City, CA 94115, USA.
John C NewmanBuck Institute for Research on Aging, Novato, CA 94945, USA.
Juan Carlos Izpisua BelmonteAltos Labs, San Diego Institute of Science, San Diego, CA 92121, USA.
Kazuto KawamuraMax Planck Institute for Biology of Ageing, Cologne, Germany.
Kennedy Matsagas SchaalRejuve Bio, Orange, CA 92867, USA.
Kitsu EgertonBaillie Gifford and Co., Edinburgh, UK.
Kotb AbdelmohsenNational Institute on Aging, National Institutes of Health (NIH), Baltimore, MD 21224, USA.
Kristen FortneyBioAge Labs, Richmond, CA 94804, USA.
Lars HartensteinMcKinsey Health Institute, New York, NY 10007, USA.
Laura NiedernhoferMasonic Institute on the Biology of Aging and Metabolism (MIBAM), University of Minnesota, Minneapolis, MN 55455, USA.
Lida KatsimpardiInstitute for Regenerative Medicine and Biotherapy (IRMB), University of Montpellier, INSERM, Montpellier, France.
Lisa MeltonNature Biotechnology, New York, NY 10013, USA.
Lotte Bjerre KnudsenNovo Nordisk A/S, Måløv, Denmark.
Luigi FerrucciNational Institute on Aging, National Institutes of Health (NIH), Baltimore, MD 21224, USA.
Lykke SylowDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Marco DemariaEuropean Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen (UMCG), University of Groningen (RUG), Groningen, The Netherlands.
Marissa J SchaferDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
Marta Guasch-FerréNovo Nordisk Center for Basic Metabolic Research and Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Martin Borch-JensenGordian Biotechnology, San Francisco, CA 94080, USA.
Maxim KholinGero, Singapore, Singapore.
Michael AntonovDeep Origin, Palo Alto, CA 94080, USA.
Michael LevittDepartment of Structural Biology, Stanford University, Stanford, CA 94304, USA.
Michela DeleidiInstitute Imagine, INSERM UMR1163, Paris, France.
Miriam MeradPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Morten MeldalDepartment of Chemistry, University of Copenhagen, Copenhagen, Denmark.
Mourad ToporsRepair Biotechnologies, Syracuse, NY 13210, USA.
Murali VenkatesanDanaher Ventures, Danaher Corporation, Washington, DC 20037, USA.
Nathan K LeBrasseurRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA.
Niklas AnzingerInfinita City, Prospera, Roatán, Honduras.
Peter FedichevGero, Singapore, Singapore.
Paul KohlhaasMolecule AG, Basel, Switzerland.
Peter J MullenDepartment of Immunology and Immune Therapeutics, Keck School of Medicine, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90033, USA.
Priya SinghalBiogen, Cambridge, MA 02142, USA.
Rafael de CaboNational Institute on Aging, National Institutes of Health (NIH), Baltimore, MD 21224, USA.
Riekelt H HoutkooperLaboratory Genetic Metabolic Diseases, Amsterdam Gastroenterology, Endocrinology and Metabolism Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Rusty MontgomeryBioAge Labs, Richmond, CA 94804, USA.
Ryan SmithTruDiagnostic Inc., Lexington, KY 40503, USA.
Sharon Rosenzweig-LipsonLife Biosciences, Boston, MA 02116, USA.
Sergey JakimovLongeVC, Washington, DC 20036, USA.
Steve HorvathAltos Labs, San Diego Institute of Science, San Diego, CA 92121, USA.
Steven AustadDepartment of Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Thomas A RandoUCLA Broad Stem Cell Research Center, Los Angeles, CA 90033, USA.
Todd WhiteThe Thalion Initiative, Boston, MA 02115, USA.
Tom ZuberZuber Lawler, Los Angeles, CA 90067, USA.
Tomaz RozmaricLudwig Boltzmann Institute for Traumatology, Vienna, Austria.
Tony Wyss-CorayDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94304, USA.
Tuomas TammelaCancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Vadim N GladyshevDivision of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
Vanessa V C SinattiAptah Bio Inc., San Carlos, CA 94070, USA.
Weilan WangCentre for Healthy Longevity, National University Health System, Singapore, Singapore.
William HarborneLongGame Ventures, London, UK.
Xiaodong LiuSchool of Life Sciences, Westlake University and Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
Xing Li WangFosun Pharma, Shanghai, China.
Yousin SuhDepartment of Obstetrics and Gynecology, Columbia University, New York, NY 10032, USA.
Yuta LeeAccelerated Biosciences Corp., Philadelphia, PA 19104, USA.
Zane KochProgram in Bioinformatics and Systems Biology, University of California, San Diego, La Jolla, CA 92093, USA.
Alex ZhavoronkovBuck Institute for Research on Aging, Novato, CA 94945, USA.
Morten Scheibye-KnudsenDepartment of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Daniela BakulaDepartment of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Funding
The role of hyaluronan in longevity and cancer resistance of longest-lived rodentP01AG047200 · NIA · UNIVERSITY OF ROCHESTER · PI Vera Gorbunova · 2014 to 2026
$36.9MValidation and characterization of the identified variants associated with human longevity in mouse modelsU19AG056278 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Zhengdong Zhang · 2017 to 2026
$24.5MThe regulation of health and longevity by branched-chain amino acidsRF1AG056771 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI LAMMING, DUDLEY WILLIAM · 2023 to 2023
$2.1MNIA NIH HHS P01 AG047200NIA NIH HHS RF1 AG056771NIA NIH HHS U19 AG056278
Abstract
The 12th Aging Research and Drug Discovery (ARDD) meeting convened at the University of Copenhagen, presenting a comprehensive overview of recent advancements in the biology of aging. A central theme across sessions was the field's gradual shift from descriptive, correlational studies to mechanistic understandings enabling the engineering of personalized therapeutic interventions aimed at extending human healthspan. Key discussions highlighted the convergence of multiple disciplines. Presentations detailed how fundamental biological insights are being integrated with artificial intelligence and machine learning platforms for accelerated target identification and drug development. Furthermore, the development and application of novel preclinical research models were presented as critical for improving the translational pipeline to human clinical trials. Scientific discourse has advanced from cataloging the established hallmarks of aging to identifying and modulating the specific molecular mechanisms that regulate them. This focus is predicated on the hypothesis that aging is not solely a result of stochastic damage accumulation but may be a tractable, modifiable, and potentially reversible biological process amenable to intervention. This report summarizes the principal research directions and conceptual frameworks presented at the conference.
Indexed as
agingbiomarkersgerosciencelongevityrejuvenation
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.