Evidence mapPaperPMID 41944865Full record

ReviewIntensive care medicine2026

Innovation in intensive care: a framework to turn ideas and concepts into actionable solutions.

Maurizio Cecconi, Massimiliano Greco, Eleonora Balzani, Ana-Maria Ioan, Elena Sancho Ferrando, Andrea Aliverti, Derek C Angus, Elie Azoulay, Elena Bignami, Lluis Blanch and 26 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Intensive care medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

Maurizio CecconiDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Massimiliano GrecoDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy. massimiliano.greco@hunimed.eu.ORCID http://orcid.org/0000-0003-1003-4637
Eleonora BalzaniCentre for Medical Sciences-CISMed, University of Trento, Trento, Italy.ORCID http://orcid.org/0000-0001-7837-4457
Ana-Maria IoanHospital Universitario Fundación Jiménez Díaz, Madrid, Spain.
Elena Sancho FerrandoDepartment of Anesthesiology and Intensive Care, Uppsala University Hospital, Uppsala, Sweden.ORCID http://orcid.org/0000-0001-6522-6252
Andrea AlivertiDipartimento di Elettronica, Informazione e Bioingegneria (DEIB), Politecnico di Milano, Milan, Italy.
Derek C AngusDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, USA.ORCID http://orcid.org/0000-0002-7026-5181
Elie AzoulayIntensive Care Department, APHP, Saint-Louis Hospital, Paris-Cité University, INSERM UMR1342 Institut de Recherche Saint-Louis, Paris, France.ORCID http://orcid.org/0000-0002-8162-1508
Elena BignamiUnit of Anesthesiology, Division of Critical Care and Pain Medicine, Department of Medicine and Surgery, University of Parma, Parma, Italy.
Lluis BlanchCritical Care Department, Parc Taulí Hospital Universitari, Institut d'Investigació I Innovació Parc Taulí (I3PT-CERCA), Sabadell, Spain.ORCID http://orcid.org/0000-0002-4158-7464
Cristiana BolchiniPolitecnico di Milano, Dip. Elettronica Informazione e Bioingegneria, Milan, Italy.
Leo CeliLaboratory for Computational Physiology, Massachusetts Institute of Technology, Cambridge, USA.
Kirsten ColpaertDepartment of Intensive Care, Ghent University Hospital, Ghent, Belgium.ORCID http://orcid.org/0000-0003-2515-1713
Andrew Conway MorrisDivision of Perioperative, Acute, Critical Care and Emergency Medicine, Department of Medicine, University of Cambridge, Cambridge, UK.
Maria Laura CostantinoPolitecnico di Milano, Dipartimento di Chimica, Materiali e Ingegneria Chimica "Giulio Natta", Milan, Italy.
Paul ElbersDepartment of Intensive Care Medicine, Center for Critical Care Computational Intelligence, Amsterdam Medical Data Science, Amsterdam Public Health, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.
Ari ErcoleDivision of Perioperative, Acute, Critical Care and Emergency Medicine, Department of Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-8350-8093
Manuela FerrarioDipartimento di Elettronica, Informazione e Bioingegneria (DEIB), Politecnico di Milano, Milan, Italy.ORCID http://orcid.org/0000-0001-7371-3624
Roberto FumagalliDepartment of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Giacomo GrasselliDepartment of Emergency, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Nicole G M HunfeldDepartment of Intensive Care Adults, Erasmus University Medical Centre, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0001-6856-7028
Carolina IaquanielloNeuroanesthesia and Intensive Care, Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.ORCID http://orcid.org/0000-0002-9105-8253
Samir JaberSaint Eloi ICU, Montpellier University Hospital, PhyMedExp, INSERM, CNRS, Montpellier, France.
Jozef KeseciogluDepartment of Intensive Care Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-3007-8445
Giovanni LandoniDepartment of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Nicola LatronicoUniversity Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Università di Brescia, Brescia, Italy.ORCID http://orcid.org/0000-0002-2521-5871
Ezinwanne OzoaniAppliedAI Institute for Europe gGmbH, Munich, Germany.ORCID http://orcid.org/0009-0006-7207-8589
Gaetano PerchiazziDepartment of Surgical Sciences, The Hedenstierna Laboratory, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0001-6834-6399
Pedro PovoaNOVA Medical School, CHRC, NOVA University of Lisbon, Lisbon, Portugal.
Jason A RobertsUniversity of Queensland Centre for Clinical Research, Faculty of Medicine The University of Queensland, Brisbane, Australia.ORCID http://orcid.org/0000-0001-6218-435X
Manu Shankar-HariCentre for Critical Illness Research, School of Immunology & Microbial Sciences, King's College London, London, UK.ORCID http://orcid.org/0000-0002-5338-2538
Maria TheodorakopoulouIntensive Care Unit I General Hospital of Attiki "KAT" Nikis 2, Kifisia, Athens, Greece.ORCID http://orcid.org/0000-0002-0385-1869
Patrick ThoralDepartment of Intensive Care Medicine, Center for Critical Care Computational Intelligence, Amsterdam Medical Data Science, Amsterdam Public Health, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.
Margo van MolDepartment of Intensive Care Adults, Erasmus University Medical Centre, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-0213-6054
Salvatore MaggioreUniversity Department of Innovative Technologies in Medicine and Dentistry, Gabriele d'Annunzio University of Chieti-Pescara, Chieti, Italy.
Jan J De WaeleDepartment of Intensive Care, Ghent University Hospital, Ghent, Belgium.ORCID http://orcid.org/0000-0003-1017-9748

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIntensive care is under increasing pressure due to demographic changes, availability of new complex therapies, and workforce shortages, resulting in a relative reduction in resources. Technological advances such as digitalization, wearable sensors, and artificial intelligence promise to improve care delivery, enabling providers to offer equal or higher-quality care at lower costs. However, no healthcare system has yet demonstrated large-scale gains in the efficiency of intensive care delivery. A central requirement is the capacity to translate ideas and concepts into value, providing changes that make services, products, and optimal care more accessible and affordable to a larger population, generating value. Innovation should thus be acknowledged as a fourth principal pillar of intensive care, alongside clinical excellence, research, and teaching.

methodsThis paper presents the opinion of a multidisciplinary expert panel, proposing a framework to support the generation, implementation, and evaluation of innovation in intensive care.

resultsWe identify and examine key areas and applications where innovation is urgently needed, including workforce development, technology adoption, environmental sustainability, and the transformation of medical education. We also highlight barriers and concerns that must be addressed when implementing innovation in ICUs. We integrate these into a comprehensive framework illustrated through concrete examples. Finally, we argue that innovation should not be driven solely by academia or industry, but strategically led by healthcare professionals and patients' representatives, grounded in ethics and data, interdisciplinary, and centered on patients' and society's needs.

conclusionThis framework offers a pathway for innovation, supporting a more inclusive, effective, and sustainable future for intensive care.

Indexed as

Critical CareDiffusion of InnovationInventionsArtificial IntelligenceDigital HealthHumansIntensive Care UnitsOrganizational InnovationArtificial intelligenceCritical careInnovationIntensive careSustainabilityWearable device

Identifiers

PMID41944865

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.