ReviewWorld journal of urology2026
Unravelling new mechanisms of occurrence and recurrence in calcium nephrolithiasis: the role of epigenetics.
Review in World journal of urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
introductionCalcium kidney stone disease, a common urinary tract disorder characterized by a high recurrence rate, remains poorly understood in terms of its recurrent etiology. Existing preventive measures are inadequate, limiting their clinical utility. Recent evidence suggests a significant role for epigenetic modifications in stone formation.
methodsBased on expert-conducted PubMed literature searches, appropriate articles focusing on the investigation of epigenetic mechanisms in calcium kidney stone disease were carefully selected for inclusion in the study.
resultsThe current understanding of calcium kidney stone disease indicates that epigenetic changes play a crucial role. Multiple studies have delved into the functions of DNA and mRNA methylation, histone and non-histone regulation, and non-coding RNA in the development of calcium kidney stones. Elucidating these molecular mechanisms holds promise for the development of more effective therapeutic and preventive strategies.
conclusionsCalcium kidney stone disease poses a challenge in clinical management due to its high recurrence rate and the suboptimal efficacy of existing preventive interventions. Although recent research has shed light on the role of epigenetic modifications in stone formation, further in-depth investigation is imperative. Continued exploration of epigenetic mechanisms will be essential for the development of more effective therapeutic and preventive strategies to improve the outcomes for patients with calcium kidney stone disease.
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41944902What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.