ReviewCellular oncology (Dordrecht, Netherlands)2026
Lactate and lactylation: metabolic architects of tumor progression and metastasis.
Review in Cellular oncology (Dordrecht, Netherlands), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Review
- The multifaceted functions of lactate and its translational potentials in cancer.Frontiers in pharmacology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Lactate and its associated modification, lactylation, have emerged as key regulators in influencing various cellular processes. This review explores the multifaceted roles of lactate and lactylation, highlighting their involvement in metabolic reprogramming and the modulation of key signaling pathways. Lactate and lactylation influence cell adhesion, protein degradation, and angiogenesis, contributing to tumor invasion and metastasis. These metabolic alterations maintain cancer stem cell characteristics, support tumorigenesis and resistance to therapy. Lactate and lactylation also facilitate immune evasion in the tumor microenvironment (TME) by modulating immune cell function and immune checkpoint pathways. The complex interplay between lactate, lactylation, and various cellular and immune mechanisms underscores the potential of targeting lactate-related pathways as a therapeutic strategy for cancer treatment. Herein, we provide a comprehensive overview of the current understanding of lactate and lactylation in cancer, offering insights into their roles as key drivers of tumor progression and metastasis.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.