ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2026
Impact of anemia prior to catheter ablation for atrial fibrillation on clinical outcomes: a U.S. retrospective cohort analysis.
Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAtrial fibrillation (AF) and anemia often coexist and are both associated with increased all-cause mortality. However, the impact of anemia on clinical outcomes in patients with AF undergoing catheter ablation remains unclear.
methodsWe conducted a retrospective analysis using the TriNetX database, covering the period from January 2016 to December 2022. Patients aged 18 years or older with AF undergoing their first catheter ablation were included. We performed a comparative analysis of patients with anemia versus those without. Propensity Score Matching (PSM) (1:1) was employed based on all baseline characteristics. The primary outcome was the recurrence of AF after a three-month blanking period over a three-year follow-up.
resultsWe included 28,064 patients who underwent their first catheter ablation, of whom 18,297 were males, and 9,767 were females. Among them, 2,315 males were anemic, and 1,441 females were anemic. PSM resulted in 2,033 male patients in each cohort and 1,338 female patients in each cohort. In the male group, anemia was significantly associated with a higher risk of AF recurrence (HR: 1.159, 95% CI [1.056, 1.273], p = 0.002), with no significant difference in the female group (HR: 1.104, 95% CI [0.985, 1.238], p = 0.089).
conclusionOur study suggests that anemia was significantly associated with a higher risk of AF recurrence in males, with no significant difference in females. In both males and females, anemia was significantly associated with increased risks of acute heart failure, bleeding, acute kidney injury, hospitalizations, and all-cause mortality.
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