Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
8 authors.
Hong Zhang *Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.ORCID 0009-0000-2774-5844
Yu Zhang *Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.ORCID 0009-0001-3316-2124
Zhifei ZhaoKey Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Zelin CaoKey Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Kexu ZhaoKey Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.ORCID 0009-0006-9448-0886
Mengshi LeiKey Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Shen WangKey Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.ORCID 0000-0002-5013-1039
Cong MaKey Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.ORCID 0000-0002-7814-0500
Funding
Hubei Provincial Natural Science Foundation of China 2024AFA005Interdisciplinary Research Programme of HUST 2023JCYJ006Interdisciplinary Research Programme of HUST 2024JCYJ011MOST | National Natural Science Foundation of China (NSFC) 32225024MOST | National Natural Science Foundation of China (NSFC) 32401035MOST | National Natural Science Foundation of China (NSFC) 32421003MOST | National Natural Science Foundation of China (NSFC) 32501097National Science and Technology Major Project () 2021ZD0202501
6 · The paper itself
Abstract
Neurotransmitter release requires the precise localization and assembly of the SNARE machinery at presynaptic release sites. Although liquid-liquid phase separation of active zone scaffolds is known to organize these sites, the mechanism for the specific enrichment of the SNARE machinery has remained unclear. In this study, we establish that within RIM1/RIM-BP2 biomolecular condensates, Munc13-1 functions as an organizational hub that spatially sorts and concentrates cognate SNAREs, orchestrating their stepwise assembly. In particular, this condensate environment empowers Munc13-1 to cluster Syb2 into nanodomains on the vesicle membrane, dramatically increasing local SNARE density and ensuring efficient complex formation. Consequently, the introduction of RIM1/RIM-BP2 into PC12 cells enhances spatiotemporally precise dense-core vesicle exocytosis in a Munc13-dependent manner. Our findings suggest a model in which phase separation creates a privileged platform that enables Munc13-1 to direct SNARE complex assembly, thereby ensuring the speed and precision of synaptic vesicle exocytosis.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Munc13 serves as a molecular filter for SNARE sorting and assembly in active zone condensates. · full record | Socratic