Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
16 authors.
Jiyeon Ha *CAMS Oxford Institute, Chinese Academy of Medical Sciences & Peking Union Medical College, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom.ORCID 0009-0003-1968-211X
Parul Sharma *Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, United Kingdom.
Sammi TaNuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, United Kingdom.ORCID 0009-0000-9912-9805
Senko TsukudaNuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, United Kingdom.ORCID 0000-0002-7289-3018
James M HarrisNuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, United Kingdom.ORCID 0000-0003-1880-3496
Rebekah Penrice-RandalDepartment of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, United Kingdom.ORCID 0000-0002-0653-2097
Eleanor BentleyDepartment of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, United Kingdom.
Adam KirbyDepartment of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, United Kingdom.
Daniele F MegaDepartment of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, United Kingdom.
David A MatthewsSchool of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom.
Peter BalfeNuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, United Kingdom.ORCID 0000-0002-6246-0876
Jan RehwinkelMedical Research Council Translational Immune Discovery Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom.ORCID 0000-0003-3841-835X
Anja Kipar *Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, United Kingdom.ORCID 0000-0001-7289-3459
James P Stewart *Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, United Kingdom.ORCID 0000-0002-8928-2037
Jane A McKeating *CAMS Oxford Institute, Chinese Academy of Medical Sciences & Peking Union Medical College, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom.ORCID 0000-0002-7229-5886
Peter A C Wing *CAMS Oxford Institute, Chinese Academy of Medical Sciences & Peking Union Medical College, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom.ORCID 0000-0002-2354-3281
Funding
Chinese Academy of Medical Sciences (CAMS) 2024-I2M-2-001-1UK Research and Innovation (UKRI) MR/W005611/1/UK Research and Innovation (UKRI) MR/W021641/1UKRI | Biotechnology and Biological Sciences Research Council (AFRC) BB/W020351/1UKRI | Biotechnology and Biological Sciences Research Council (AFRC) UKRI3565UKRI | MRC | Medical Research Council Laboratory of Molecular Biology (LMB) MR/Y013212/1Wellcome Trust (WT) 225198/Z/22/Z
6 · The paper itself
Abstract
The immune mechanisms responsible for protection and pathogenesis in pneumoviral infection are not well defined. We demonstrated that pharmacological activation of the hypoxic inducible factor (HIF) signaling axis using daprodustat limited viral replication through enhanced immune signaling. Transcriptomic analysis revealed HIF augmented activation of innate immune response genes, including interferon-stimulated gene 15 (
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Hypoxia inducible factors regulate pneumovirus replication by enhancing innate immune sensing. · full record | Socratic