Evidence map›Paper›PMID 41945530›Full record

ArticleJACC. Case reports2025

Zero-Contrast PCI in a Patient With Recurrent Anaphylaxis to Contrast.

Philip M LaCombe, Muhammad F Anwaar, Neal S Kleiman, Alpesh R Shah

Abstract readCase Reports
In one paragraph

Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Philip M LaCombeInterventional Cardiology, Houston Methodist Hospital, Houston, Texas, USA. Electronic address: lacombep123@gmail.com.
Muhammad F AnwaarInterventional Cardiology, Houston Methodist Hospital, Houston, Texas, USA.
Neal S KleimanInterventional Cardiology, Houston Methodist Hospital, Houston, Texas, USA.
Alpesh R ShahInterventional Cardiology, Houston Methodist Hospital, Houston, Texas, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIodinated contrast media (ICM) are important for percutaneous coronary intervention (PCI) but can trigger life-threatening reactions in sensitized patients. Alternative strategies are needed for safe revascularization. CASE SUMMARY: A 59-year-old woman with heart failure, diabetes, and prior ICM-induced anaphylactoid reaction presented with stable angina. Angiography showed severe left anterior descending and left posterior descending artery stenosis. She declined coronary artery bypass grafting and experienced recurrent severe anaphylactoid reactions during PCI attempts despite premedication. After desensitization, she underwent successful zero-contrast PCI using intravascular ultrasound and previous imaging as a guide. DISCUSSION: This case highlights the limitations of premedication alone in preventing ICM reactions and supports the use of zero-contrast PCI. The literature demonstrates its safety and feasibility, even in complex lesions, offering a valuable alternative for high-risk patients. TAKE-HOME MESSAGE: Zero-contrast PCI is a safe and effective option for patients with ICM hypersensitivity.

Indexed as

anaphylaxiscontrast agentpercutaneous coronary intervention stentspremedication

Identifiers

PMID41945530
PMCPMC12802586

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.