ArticleCPT: pharmacometrics & systems pharmacology2026
The Role of Estradiol in Oxidative Stress in Health and Cystathionine ß-Synthase Deficiency: A Mechanistic Model.
Article in CPT: pharmacometrics & systems pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Oxidative stress occurs when there is an imbalance between oxidants and antioxidants, leading to the accumulation of reactive oxygen species (ROS). Excessive ROS can damage lipids, proteins, and DNA, contributing to cellular dysfunction and disease. Interestingly, premenopausal females tend to have lower levels of oxidative stress and higher concentrations of certain antioxidants, such as glutathione (GSH), compared to males and postmenopausal females. These differences point to the important role of sex hormones in regulating oxidative stress and its effects on the body. Yet, clinical and experimental studies report conflicting effects of estradiol, particularly across the menstrual cycle in premenopausal females and in estradiol supplementation in postmenopausal females. Here, we present a mechanistic mathematical model of hydrogen peroxide (H
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