ArticleJournal of nanobiotechnology2026
Enhanced mRNA vaccine combined with immune checkpoint blockade efficiently suppresses tumor growth and metastasis.
Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
8 authors.
Funding
Abstract
Recently, mRNA vaccines have successfully prevented infectious diseases but remain only adjuvant therapies for cancer due to limited immune killing efficacy. The efficacy of tumor vaccines depends on both the immunogenicity of associated antigens and the delivery efficacy of lipid nanoparticles (LNPs). While next-generation sequencing has optimized neoantigen identification pipelines, most delivery systems still employ LNP formulations originally developed for infectious disease vaccines. Critically, most infectious disease vaccines primarily rely on humoral immunity for prophylaxis, whereas therapeutic tumor vaccines predominantly depend on cellular immunity for tumor eradication. Due to these mechanistic differences, developing delivery systems specifically designed for mRNA tumor vaccines is crucial. Herein, we constructed a mannose-functionalized LNP (MRLNP) that co-delivers tumor antigen-encoding mRNA and the TLR7/8 agonist resiquimod (R848). Mannose modification promotes lymph node drainage and dendritic cell (DC)-targeted uptake. R848 boosts antigen immunogenicity, driving DC maturation and antigen presentation to robustly activate cellular immunity. In the B16F10-OVA subcutaneous tumor model, MRLNP/mOVA vaccine combined with the anti-PD-1 antibody achieved a 93.5% tumor suppression rate. Furthermore, long-term immune memory generated by combination therapy effectively prevented lung metastasis formation in tumor rechallenge experiments. Collectively, this work establishes that MRLNP, as a novel enhanced delivery system, holds great potential for the development of highly effective mRNA tumor vaccines and combination therapies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.