Evidence map›Paper›PMID 41947411›Full record

ArticleRenal failure2026

Erythropoietin receptor upregulation is associated with tubular injury severity in human acute kidney injury.

Kun Xie, Gang Zhou, Mengjin Li, Lili Fu, Rong Wang, Liming Zhang, Changlin Mei, Cheng Xue, Daoliang Xu

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In one paragraph

Article in Renal failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Kun XieDepartment of Nephrology, Northern Jiangsu People's Hospital, Clinical Medicine College, Yangzhou University, Yangzhou, China.
Gang ZhouDepartment of Nephrology, Northern Jiangsu People's Hospital, Yangzhou, China.
Mengjin LiDivision of Nephrology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.
Lili FuDivision of Nephrology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.
Rong WangDepartment of Nephrology, Northern Jiangsu People's Hospital, Yangzhou, China.
Liming ZhangDivision of Nephrology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.
Changlin MeiDivision of Nephrology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.
Cheng XueDivision of Nephrology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.ORCID 0000-0002-4132-9406
Daoliang XuDepartment of Nephrology, Northern Jiangsu People's Hospital, Clinical Medicine College, Yangzhou University, Yangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to investigate erythropoietin receptor (EPOR) expression in human AKI and to examine its association with histopathological severity and clinical parameters.

methodsRenal biopsy specimens from 21 patients with biopsy-confirmed acute kidney injury (AKI) and 12 control kidney tissues from nephrectomy samples were analyzed. EPOR expression was assessed by immunohistochemistry with AI-assisted digital quantification and by immunofluorescence, including co-staining with β-common receptor (βcR) and TUNEL.

resultsIn human kidney biopsy specimens, EPOR expression was significantly higher in AKI kidneys compared to controls (

conclusionsEPOR expression is upregulated in renal tubular epithelial cells in human AKI and is closely associated with histopathological injury severity and selected clinical parameters, highlighting that EPOR may serve as a marker of tubular stress and injury severity in AKI.

Indexed as

Acute Kidney InjuryKidney TubulesReceptors, ErythropoietinAdultAgedAnimalsBiopsyCase-Control StudiesFemaleHumansImmunohistochemistryMaleMiceMiddle AgedROC CurveSeverity of Illness IndexReceptors, Erythropoietinacute kidney injuryErythropoietinerythropoietin receptortubular necrosis

Identifiers

PMID41947411
PMCPMC13063319

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.