Trial reportJournal of cosmetic dermatology2026
Prospective, Randomized, Double-Blind, Placebo-Controlled Study of an Oral Antioxidant-Rich Synbiotic Supplement on Skin Health and Photoaging.
Trial report in Journal of cosmetic dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
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Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundPhotoaged skin is primarily induced by prolonged exposure to ultraviolet radiation, leading to increased pigmentation, reduced elasticity, and pronounced wrinkles. There has been an increasing recognition of the influence of nutrition on skin health, with dietary elements emerging as a viable alternative approach to preventing photoaging. This study explores how oral supplementation impacts photoaged skin, hydration, and elasticity.
aimsThis study evaluates the effects of an antioxidant-rich synbiotic supplement on facial elasticity, hydration, and photoaging markers, such as erythema and pigmentation. PATIENTS/
methodsIn this 8-week study, 36 participants from the Sacramento region were randomized to receive either the antioxidant-rich synbiotic supplement or a placebo. Participants had 3 visits: baseline, week 4, and week 8. Noninvasive facial measurements, including hydration, elasticity, erythema, and pigmentation, were obtained. Facial photography and analysis were performed. Tolerability was assessed.
resultsAt week 8, the treatment group showed a significant reduction in wrinkle severity (-5.28%, p < 0.01), whereas the placebo group did not. Cheek elasticity increased significantly at week 4 (22.0%, p < 0.01) and week 8 (13.8%, p < 0.05), along with firmness at week 8 (12.2%, p < 0.01). The placebo group showed no significant changes in these parameters. Additionally, the viscoelasticity of the cheek increased at week 4 (30.2%, p < 0.01) in the treatment group, with no change in the placebo group.
conclusionsThe antioxidant-rich synbiotic supplement improved wrinkle severity, skin facial elasticity, and skin firmness, enhancing several parameters of photoaging.
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