Evidence map›Paper›PMID 41947476›Full record

ReviewVirulence2026

PRRSV subverts host programmed cell death network for immune evasion.

Shengming Ma, Qian Mao, Shaoting Weng, Kaiqi Lian, Zhihui Jiang, Jie Hao, Kunpeng Zhang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Virulence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shengming MaSchool of Biological and Food Engineering, Anyang Institute of Technology, Anyang, People's Republic of China.
Qian MaoSchool of Biological and Food Engineering, Anyang Institute of Technology, Anyang, People's Republic of China.ORCID 0009-0006-8414-6809
Shaoting WengSchool of Biological and Food Engineering, Anyang Institute of Technology, Anyang, People's Republic of China.
Kaiqi LianSchool of Biological and Food Engineering, Anyang Institute of Technology, Anyang, People's Republic of China.
Zhihui JiangSchool of Biological and Food Engineering, Anyang Institute of Technology, Anyang, People's Republic of China.
Jie HaoSchool of Biological and Food Engineering, Anyang Institute of Technology, Anyang, People's Republic of China.
Kunpeng ZhangSchool of Biological and Food Engineering, Anyang Institute of Technology, Anyang, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) is a major pathogen endangering the global swine industry, causing severe reproductive disorders in sows and respiratory diseases in piglets, and incurring substantial economic losses. This review summarizes how PRRSV interferes with multiple programmed cell death (PCD) modalities, including apoptosis, autophagy, pyroptosis, and ferroptosis, thereby optimizing its replication microenvironment, evading host immune responses, and establishing persistent infection. Furthermore, it details the spatiotemporal-specific strategies of PRRSV in regulating PCD during different infection stages and in various cell types, and highlights the pivotal role of virus-host protein interactions in viral pathogenesis. Collectively, this review systematically elucidates the molecular mechanisms by which PRRSV manipulates the host PCD network, and provides crucial theoretical guidance for PRRSV control research and antiviral drug development.

Indexed as

Immune EvasionPorcine respiratory and reproductive syndrome virusRegulated Cell DeathAnimalsMolecular Targeted TherapyPorcine Reproductive and Respiratory SyndromeSwineVirus Replicationautophagyimmune evasionpersistent infectionPorcine reproductive and respiratory syndrome virusprogrammed cell death

Identifiers

PMID41947476
PMCPMC13064560

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.