ArticleReproductive medicine and biology
Expression and Function of Meflin in Human Endometrial Decidualization.
Article in Reproductive medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Correction to "Expression and Function of Meflin in Human Endometrial Decidualization".Reproductive medicine and biologyArticle
Corrections and comments
- Erratum issued
- Erratum issued
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Decidualization of endometrial stromal cells involves significant morphological and functional changes in which alpha-smooth muscle actin (αSMA) expression decreases. Meflin, a glycosylphosphatidylinositol-anchored protein, suppresses αSMA expression and inhibits fibrosis in various tissues. Therefore, we investigated whether Meflin regulates decidualization by modulating αSMA expression. Methods: Meflin protein expression was evaluated in human endometrial tissues using immunohistochemistry. Immortalized endometrial stromal cells were used for in vitro experiments. The effects of decidualization on Meflin were assessed using 17β-estradiol, progesterone, and dibutyryl cyclic AMP treatments and analyzed using quantitative polymerase chain reaction, western blotting, and collagen gel contraction assays. The role of Meflin was investigated by performing an overexpression assay. Results: Meflin expression was significantly higher in the secretory-phase endometrium than in the proliferative-phase endometrium and was inversely correlated with αSMA expression. In vitro decidualization increased Meflin expression while suppressing that of αSMA. Meflin overexpression decreased αSMA expression and contractility, induced morphological changes from spindle-shaped to polygonal cells, and attenuated Conclusion: Meflin functions as a regulator of endometrial decidualization by modulating αSMA expression and cellular contractility. The evaluation of Meflin expression may provide insights into disorders associated with impaired decidualization, such as infertility and endometriosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.