ArticleClinical kidney journal2026
Older females with late-onset hypertension are at higher CKD risk than males.
Article in Clinical kidney journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
13 authors.
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Abstract
Background: Females develop hypertension later and are less likely to receive chronic kidney disease (CKD) prevention treatments. The long-term impact of these differences remains unclear. We aimed to investigate sex-based differences in the in CKD outcomes among older adults with hypertension. Methods: We conducted a population-based retrospective cohort study of adults aged ≥66 years with new hypertension using linked health data from Ontario, Canada (1 January 2010, to 31 December 2021). The primary composite outcome was a 40% decline in estimated glomerular filtration rate (eGFR) or kidney failure. We used Cox proportional hazards models to calculate hazard ratios (HRs) and Fine-Gray models accounting for death as a competing risk (subdistribution HRs, sHRs). Results: Incident hypertension developed in 121 490 individuals (57.7% female; mean age 73.1 years; mean eGFR 83.2 mL/min/1.73 m²; median follow-up 6.8 years), 17 343 (14.3%) experienced the composite kidney outcome. The crude incidence rate per 1000 person-years was higher for females compared with males (22.0 in females vs 21.1 in males; Conclusion: Older females with new onset hypertension were more likely to develop a 40% decline in eGFR or kidney failure compared with older males. This study will inform hypertension management practices in aging populations.
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Registered trials
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