ArticleFrontiers in cardiovascular medicine2026
Is the effect of antihypertensive drug therapy on blood pressure control and prevalent cardiovascular disease associated with dietary sodium-potassium ratio? A cross-sectional study based on NHANES.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To evaluate whether antihypertensive treatment strategy and dietary sodium-to-potassium (Na/K) ratio are associated with blood pressure (BP) control and cardiovascular disease (CVD), and whether Na/K interacts with treatment effects. Methods: We analyzed 4,800 treated hypertensive adults (BP control defined as <130/80 mmHg) from NHANES 2009-2018 using survey-weighted logistic models and interaction analyses. Parallel endothelial experiments were performed in HUVECs exposed to normal or high Na/K, Ang II, and antihypertensive drugs. Results: Combination therapy was not associated with improved BP control (OR = 0.89; Conclusions: Pharmacologic treatment intensity and dietary Na/K ratio appeared to influence vascular outcomes independently in treated hypertension. Critically, the lack of dietary Na/K effect modification in the clinical population is biologically explained by the maintained drug efficacy under high Na/K conditions.
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