Evidence map›Paper›PMID 41948286›Full record

ArticleFrontiers in nutrition2026

Clinical implications of malnutrition in Huntington's disease progression: evidence from a Chinese cohort and Mendelian randomization.

Jie-Qiang Xia, Yang-Fan Cheng, Si-Rui Zhang, Yuan-Zheng Ma, Jia-Jia Fu, Tian-Mi Yang, Ling-Yu Zhang, Jean-Marc Burgunder, Hui-Fang Shang

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Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Jie-Qiang Xia *Department of Neurology, Laboratory of Neurodegenerative Disorders, Rare Disease Center, West China Hospital, Sichuan University, Chengdu, China.
Yang-Fan Cheng *Department of Neurology, Laboratory of Neurodegenerative Disorders, Rare Disease Center, West China Hospital, Sichuan University, Chengdu, China.
Si-Rui ZhangDepartment of Neurology, Laboratory of Neurodegenerative Disorders, Rare Disease Center, West China Hospital, Sichuan University, Chengdu, China.
Yuan-Zheng MaDepartment of Neurology, Laboratory of Neurodegenerative Disorders, Rare Disease Center, West China Hospital, Sichuan University, Chengdu, China.
Jia-Jia FuDepartment of Neurology, Laboratory of Neurodegenerative Disorders, Rare Disease Center, West China Hospital, Sichuan University, Chengdu, China.
Tian-Mi YangDepartment of Neurology, Laboratory of Neurodegenerative Disorders, Rare Disease Center, West China Hospital, Sichuan University, Chengdu, China.
Ling-Yu ZhangDepartment of Neurology, Laboratory of Neurodegenerative Disorders, Rare Disease Center, West China Hospital, Sichuan University, Chengdu, China.
Jean-Marc BurgunderDepartment of Neurology, Laboratory of Neurodegenerative Disorders, Rare Disease Center, West China Hospital, Sichuan University, Chengdu, China.
Hui-Fang Shang *Department of Neurology, Laboratory of Neurodegenerative Disorders, Rare Disease Center, West China Hospital, Sichuan University, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Huntington's disease (HD) is a neurodegenerative disorder associated with progressive motor, cognitive, and psychiatric dysfunction. Peripheral metabolic disturbances, including malnutrition, are commonly observed in HD. However, the prevalence, clinical correlations, and prognostic value of malnutrition in HD, especially among Chinese patients, remain inadequately explored. Methods: This cohort study recruited 113 genetically confirmed HD patients and 113 age/sex-matched healthy controls (HCs). Nutritional status was assessed using the Controlling Nutritional Status (CONUT) score, Geriatric Nutritional Risk Index (GNRI), and Prognostic Nutritional Index (PNI). Clinical evaluations included Unified Huntington's Disease Rating Scale (UHDRS), cognitive tests, and psychiatric assessments. Kaplan-Meier survival analysis and Cox regression models were used to evaluate the prognostic significance of malnutrition. Mendelian randomization (MR) analysis was employed to explore causal relationships between nutritional indicators and HD progression using genome-wide association study (GWAS) data. Results: During a mean follow-up of 5.74 years, 44 patients reached composite endpoints of death or loss of independent function [total functional capacity (TFC) ≤ 2]. HD patients showed higher malnutrition prevalence than HCs (CONUT: 34.51 vs. 13.27%; GNRI: 7.96 vs. 2.65%). Malnutrition correlated with functional decline, cognitive impairment, advanced disease stage, and lower composite Unified Huntington's Disease Rating Scale (cUHDRS) score, but not with survival outcomes. MR analysis suggests a causal relationship between lymphocyte count and delayed motor progression in HD patients. Conclusion: Malnutrition was highly prevalent in Chinese HD patients and was associated with functional and cognitive decline. Although malnutrition did not independently predict survival, MR analysis suggests that lymphocytes delay motor progression, implying that immunonutritional pathways may warrant further investigation as potential targets for future mechanistic and interventional research.

Indexed as

CONUTGNRIHuntington's diseasemalnutritionnutritional statusPNI

Identifiers

PMID41948286
PMCPMC13050713

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