Single-center experience description of surgical management of diffuse congenital hyperinsulinism in a pediatric non-current cohort.

Xiaoxiang Li, Congli Chen, Yangmingyue Ji, Yuxi Wang, Yanmei Sang

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In one paragraph

Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Xiaoxiang Li *Department of Endocrinology, Genetics and Metabolism, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Congli Chen *Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.

Yangmingyue JiDepartment of Endocrinology, Genetics and Metabolism, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Yuxi WangDepartment of Endocrinology, Genetics and Metabolism, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Yanmei SangDepartment of Endocrinology, Genetics and Metabolism, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: In this study, we describe surgical indications, procedure selection, and postoperative outcomes in Chinese children with diffuse congenital hyperinsulinism (DCHI). Pancreatic involvement was assessed using Methods: Clinical and genetic characteristics were summarized for 27 children with DCHI, stratified into a surgical group ( Results: Of the 27 patients with medically refractory diffuse congenital hyperinsulinism, 12 (44.4%) required surgical intervention, including subtotal pancreatectomy (STP, n = 6) and near-total pancreatectomy (NTP, Conclusions: Subtotal and near-total pancreatectomy were not observed to result in major perioperative complications in this cohort of Chinese pediatric patients with medically refractory DCHI. Clinicians may need to carefully balance hypoglycemia control against the frequency of postoperative diabetes when selecting the extent of resection. Early diagnosis, timely hypoglycemia management, and structured long-term follow-up are essential to optimize long-term outcomes.

Indexed as

Congenital HyperinsulinismPancreatectomyChildChild, PreschoolFemaleFollow-Up StudiesHumansInfantInfant, NewbornKcnj11 ChannelMaleRetrospective StudiesSulfonylurea ReceptorsTreatment OutcomeKcnj11 ChannelSulfonylurea ReceptorsABCC8 proteincongenital hyperinsulinismdiffuseKCNJ11 proteinneurodevelopmental disorderspancreatectomypancreatectomy outcomesstudy cohort

Identifiers

PMID41948559

DOI10.3389/fendo.2026.1760749

PMCPMC13050746

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.