ArticleFrontiers in medicine2026
Prognostic associations of vitamin D deficiency with disease severity, survival, and complications in alcohol-related liver disease.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Vitamin D deficiency has been associated with adverse outcomes in various chronic diseases, and its relevance in alcohol-related liver disease (ALD) has attracted increasing attention. This study aimed to evaluate the prognostic significance of vitamin D status in hospitalized patients with ALD. Methods: We retrospectively analyzed 115 hospitalized patients with ALD between 2021 and 2024. Vitamin D deficiency was defined as serum 25-hydroxyvitamin D [25(OH)D] < 20 ng/mL. Statistical analyses were performed using Spearman's correlation, logistic regression, Kaplan-Meier survival analysis, multivariable Cox proportional hazards models, and receiver operating characteristic (ROC) curve analysis. Results: Vitamin D deficiency was present in 35.7% of patients. After adjustment for season, vitamin D deficiency was associated with alcoholic hepatitis, cirrhosis, ascites, sarcopenia, total bilirubin, Model for End-Stage Liver Disease score, and Maddrey discriminant function ≥ 32 (all Conclusion: In this cohort of hospitalized ALD patients, vitamin D deficiency was associated with greater disease severity, reduced survival, and increased risk of sarcopenia and SBP. Serum 25(OH)D may serve as a prognostic marker of overall disease burden. Given the retrospective design, limited event numbers, and short follow-up, these findings should be considered exploratory and require confirmation in prospective studies.
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