ReviewJournal of inflammation research2026
The Role of Histone Modifications in Acute Lung Injury: Molecular Mechanisms and Potential of Traditional Chinese Medicine Treatment.
Review in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening conditions characterized by excessive inflammation, alveolar-capillary barrier disruption, and immunothrombosis. Mortality remains persistently high due to the lack of effective targeted therapies. Emerging evidence indicates that histone post-translational modifications (PTMs) play dual regulatory roles by modulating intranuclear gene transcription and, upon extracellular release, amplifying damage-associated molecular pattern (DAMP) signaling. Scope: This review proposes a unified pathological framework termed the "Nuclear Epigenetic Remodeling‒Extracellular DAMP Amplification Circuit." By conceptualizing this as an inside-out pathological cascade, we integrate four principal histone modifications-acetylation, methylation, lactylation, and citrullination-and evaluate three-tiered therapeutic strategies alongside the unique multi-target potential of traditional Chinese medicine (TCM). Key Findings: Mechanistically, intranuclear HDAC3/6 drive inflammatory gene expression and pyroptosis, while cytoprotective SIRT1/3/6 suppress inflammasome activation and ferroptosis; concurrently, histone lactylation at H3K18 and H3K14 bridges glycolytic metabolism with ferroptosis and glycocalyx degradation; ultimately, externalized citrullinated histone H3 (CitH3) propagates a thrombo-inflammatory cascade driving NET-mediated immunothrombosis. Corresponding to this cascade, TCM-derived interventions collectively show promising potential to act across all therapeutic tiers by modulating the HDAC/SIRT acetylation axis, suppressing the PAD4-CitH3-NETs cascade, and regulating lactylation-linked metabolic pathways. Conclusion: We propose a precision medicine approach integrating dynamic epigenetic biomarkers (eg, serum CitH3 and H3K18la) with a multi-tiered intervention framework. This paradigm aims to shift ALI/ARDS treatment from empirical supportive care toward mechanism-based, individualized targeted therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.