Evidence map›Paper›PMID 41948823›Full record

ArticleHypertension (Dallas, Tex. : 1979)2026

Initiating Events of Retinopathy in Spontaneously Hypertensive Rats: Microvascular Rarefaction and Functional Deficits.

Tengda Huang, Jingyan Peng, Cong Li, Yun Ren, Yu Kuang, Wenli Zhang, Ying Yao, Yan Wang, Zhenchao Du, Xue He and 7 more

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Article in Hypertension (Dallas, Tex. : 1979), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

17 authors.

Tengda HuangSchool of Medicine, South China University of Technology, Guangzhou, People's Republic of China (T.H., Y.W., J.H., X.Y.).
Jingyan PengDepartment of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, People's Republic of China (T.H., J.P., C.L., Y.R., Y.K., W.Z., Y.Y., Y.W., Z.D., X.H., Z.P., H.L., Y.Z., J.H., H.Y., L.L.,X.Y.).ORCID 0009-0009-1804-7695
Cong LiDepartment of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, People's Republic of China (T.H., J.P., C.L., Y.R., Y.K., W.Z., Y.Y., Y.W., Z.D., X.H., Z.P., H.L., Y.Z., J.H., H.Y., L.L.,X.Y.).
Yun RenDepartment of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, People's Republic of China (T.H., J.P., C.L., Y.R., Y.K., W.Z., Y.Y., Y.W., Z.D., X.H., Z.P., H.L., Y.Z., J.H., H.Y., L.L.,X.Y.).ORCID 0000-0002-8161-5925
Yu KuangDepartment of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, People's Republic of China (T.H., J.P., C.L., Y.R., Y.K., W.Z., Y.Y., Y.W., Z.D., X.H., Z.P., H.L., Y.Z., J.H., H.Y., L.L.,X.Y.).
Wenli ZhangDepartment of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, People's Republic of China (T.H., J.P., C.L., Y.R., Y.K., W.Z., Y.Y., Y.W., Z.D., X.H., Z.P., H.L., Y.Z., J.H., H.Y., L.L.,X.Y.).
Ying YaoDepartment of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, People's Republic of China (T.H., J.P., C.L., Y.R., Y.K., W.Z., Y.Y., Y.W., Z.D., X.H., Z.P., H.L., Y.Z., J.H., H.Y., L.L.,X.Y.).
Yan WangSchool of Medicine, South China University of Technology, Guangzhou, People's Republic of China (T.H., Y.W., J.H., X.Y.).ORCID 0009-0009-1064-9667
Zhenchao DuDepartment of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, People's Republic of China (T.H., J.P., C.L., Y.R., Y.K., W.Z., Y.Y., Y.W., Z.D., X.H., Z.P., H.L., Y.Z., J.H., H.Y., L.L.,X.Y.).ORCID 0000-0002-0286-9653
Xue HeDepartment of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, People's Republic of China (T.H., J.P., C.L., Y.R., Y.K., W.Z., Y.Y., Y.W., Z.D., X.H., Z.P., H.L., Y.Z., J.H., H.Y., L.L.,X.Y.).
Zhishen PengDepartment of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, People's Republic of China (T.H., J.P., C.L., Y.R., Y.K., W.Z., Y.Y., Y.W., Z.D., X.H., Z.P., H.L., Y.Z., J.H., H.Y., L.L.,X.Y.).
Heng LiDepartment of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, People's Republic of China (T.H., J.P., C.L., Y.R., Y.K., W.Z., Y.Y., Y.W., Z.D., X.H., Z.P., H.L., Y.Z., J.H., H.Y., L.L.,X.Y.).ORCID 0009-0002-7859-4139
Yi ZhangDepartment of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, People's Republic of China (T.H., J.P., C.L., Y.R., Y.K., W.Z., Y.Y., Y.W., Z.D., X.H., Z.P., H.L., Y.Z., J.H., H.Y., L.L.,X.Y.).
Jianuo HanSchool of Medicine, South China University of Technology, Guangzhou, People's Republic of China (T.H., Y.W., J.H., X.Y.).
Honghua YuDepartment of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, People's Republic of China (T.H., J.P., C.L., Y.R., Y.K., W.Z., Y.Y., Y.W., Z.D., X.H., Z.P., H.L., Y.Z., J.H., H.Y., L.L.,X.Y.).ORCID 0000-0002-0782-346X
Lei LiuDepartment of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, People's Republic of China (T.H., J.P., C.L., Y.R., Y.K., W.Z., Y.Y., Y.W., Z.D., X.H., Z.P., H.L., Y.Z., J.H., H.Y., L.L.,X.Y.).ORCID 0009-0009-1807-7296
Xiaohong YangSchool of Medicine, South China University of Technology, Guangzhou, People's Republic of China (T.H., Y.W., J.H., X.Y.).ORCID 0000-0001-9466-7591

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTarget organ damage is crucial for hypertension risk stratification. However, the lack of sensitive assessment tools for early target organ damage in the presence of elevated blood pressure limits timely intervention. This study used the retina to investigate subclinical neurovascular damage and identify early imaging biomarkers.

methodsWe monitored male spontaneously hypertensive rats and Wistar-Kyoto controls weekly from 4 to 9 weeks of age. Weekly assessments included noninvasive blood pressure and multimodal fundus imaging, including optical coherence tomography, optical coherence tomography angiography and electroretinography. Histological analyses and fluorescein fundus angiography validated structural microvascular changes and blood-retinal barrier integrity.

resultsThe blood pressure of spontaneously hypertensive rats increased significantly from 5 weeks of age (

conclusionsIn spontaneously hypertensive rats, superficial microvascular rarefaction and inner retinal dysfunction represent the initiating pathological events, preceding blood-retinal barrier breakdown and macrovascular remodeling. Optical coherence tomography angiography-quantified superficial vascular plexus density is a sensitive and objective imaging biomarker for assessing retinal damage during the prehypertensive stage, which significantly precedes macrovascular signs.

Indexed as

HypertensionHypertensive RetinopathyMicrovascular RarefactionRetinaRetinal VesselsAnimalsBlood PressureBlood-Retinal BarrierDisease Models, AnimalElectroretinographyFluorescein AngiographyMaleRatsRats, Inbred SHRRats, Inbred WKYTomography, Optical Coherenceblood pressurehypertensionmicrocirculationrats, inbred SHRretina

Identifiers

PMID41948823
PMCPMC13275080

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.