Evidence map›Paper›PMID 41949064›Full record

ArticleGut microbes2026

The JNK2-microbiome axis modulates gut barrier integrity through microbial acetate.

Chen Chongtham, Trisha Biswas, Namaste Kumari, Raunak Kar, Jyotsna, Jayalakshmi S, Archana Pant, Veena S Patil, Gopalakrishnan Aneeshkumar Arimbasseri

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chen ChongthamMolecular Genetics Laboratory, National Institute of Immunology, New Delhi, India.
Trisha BiswasMolecular Genetics Laboratory, National Institute of Immunology, New Delhi, India.
Namaste KumariMolecular Genetics Laboratory, National Institute of Immunology, New Delhi, India.
Raunak KarImmunogenomics Laboratory, National Institute of Immunology, New Delhi, India.
JyotsnaImmunometabolism Laboratory, National Institute of Immunology, New Delhi, India.
Jayalakshmi SMolecular Genetics Laboratory, National Institute of Immunology, New Delhi, India.
Archana PantMolecular Genetics Laboratory, National Institute of Immunology, New Delhi, India.
Veena S PatilImmunogenomics Laboratory, National Institute of Immunology, New Delhi, India.
Gopalakrishnan Aneeshkumar ArimbasseriMolecular Genetics Laboratory, National Institute of Immunology, New Delhi, India.ORCID 0000-0001-5266-2688

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWeaning involves a nutritional shift from fat-rich milk to carbohydrate-based solid food, reshaping metabolism, microbiota, and gut immune tolerance. While dairy remains a component of the human diet beyond weaning, the impact of continued milk supplementation on gut epithelial homeostasis remains poorly understood.

resultHere, using a mouse model, we show that continued milk-based feeding post-weaning promotes intestinal barrier function by enriching the commensal bacterium

conclusionOur findings show that immediate post-weaning milk supplementation preserves a beneficial gut microbiome, marked by the persistence of

Indexed as

AcetatesGastrointestinal MicrobiomeIntestinal MucosaMitogen-Activated Protein Kinase 9AnimalsFemaleIntestinal Barrier FunctionMiceMice, Inbred C57BLMilkWeaningAcetatesMitogen-Activated Protein Kinase 9gut barriergut microbiomeinflammationJNK2 pathwayP38 pathwayWeaning

Identifiers

PMID41949064
PMCPMC13089537

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.