ReviewInvestigative ophthalmology & visual science2026
Age-Related Neurovascular Dysfunction in the Retina and Potential Pathogenic Mechanisms.
Review in Investigative ophthalmology & visual science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
3 authors.
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Abstract
With the accelerating global demographic shift toward an aging population, retinal aging has emerged as a major contributor to visual decline in older individuals and represents a key risk factor for several age-associated ocular diseases. Age-associated changes in the retinal neurovascular system have been increasingly investigated as potential contributors to the structural and functional alterations observed during normal retinal aging. Neurons, glial cells, and vascular endothelial cells exhibit age-related structural and metabolic adaptations, which may influence vascular regulation and tissue homeostasis in the aging retina. Alterations in components of the neurovascular unit have been proposed to affect metabolic coupling, vascular regulation, and inflammatory signaling. This review systematically summarizes the alterations in neurovascular anatomy and changes in function during retinal aging, and discusses mechanistic insights and emerging strategies that may help to preserve retinal resilience during aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.